G8546
p38γ, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
ERK3, ERK6, MAPK12, PRKM12, SAPK3
重组
expressed in baculovirus infected Sf9 cells
质量水平
产品线
PRECISIO® Kinase
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
比活
56-76 nmol/min·mg
分子量
~71 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... MAPK12(6300)
一般描述
p38γ, commonly known as MAPK12 (mitogen-activated protein kinase 12), is one of the four isoforms of the p38 MAPK family. This isoform shows predominant expression in skeletal muscle and is controlled by exercise.
生化/生理作用
p38γ is a key protein of the MAPK (mitogen-activated protein kinase) pathway and is involved in cell differentiation, growth, cycle and apoptosis and inflammation. It is essential for normal localization of polo-like kinase 1 (Plk1) at the kinetochore. This protein facilitates mitotic cell viability and suppresses chromosomal instability. Studies suggest that this protein negatively controls the expression of GLUT4 (glucose transporter) and the uptake of glucose mediated by contraction in adult skeletal muscles.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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