G8923
GANT58
≥98% (HPLC)
别名:
2,3,4,5-Tetra(4-pyridyl)thiophene, 4,4′,4′′,4′′′-Thiene-2,3,4,5-tetrayltetrapyridine
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关于此项目
经验公式（希尔记法）:
C24H16N4S
化学文摘社编号:
分子量:
392.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
InChI
1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
SMILES string
c1cc(ccn1)-c2sc(-c3ccncc3)c(-c4ccncc4)c2-c5ccncc5
InChI key
USWLOKMMUTWFMD-UHFFFAOYSA-N
assay
≥98% (HPLC)
color
white to pale yellow
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
GANT58 is a Hedgehog signaling pathway inhibitor.
GANT58 is a Hedgehog signaling pathway inhibitor. GANT58 inhibits the hedgehog signaling pathway downstream of Smo. GANT58 inhibits Gli transcriptional activity, and reduces cellular levels of the Hh pathway components Gli1, Shh, and patched.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Alessandra Ciucci et al.
PloS one, 8(3), e60145-e60145 (2013-04-05)
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, glioblastoma, melanoma as well as pancreas, colorectal, and prostate carcinomas. Here we investigated the role of the transcription factor Gli1 in ovarian cancer.
Shen Gu et al.
Biochemical and biophysical research communications, 533(4), 770-778 (2020-09-30)
Microcystin-leucine-arginine (MC-LR), produced by cyanobacteria, accumulates in the liver through blood circulation. We investigated the impact of MC-LR on liver fibrosis. Mice received a daily injection of MC-LR at various concentrations for 14 consecutive days aa and then mouse liver
Z I Thomas et al.
British journal of cancer, 104(10), 1575-1586 (2011-04-21)
Inflammatory breast cancer (IBC) is an aggressive subtype of breast cancer with distinct molecular profiles. Gene expression profiling previously identified sonic hedgehog (SHH) as part of a gene signature that is differentially regulated in IBC patients. The effects of reducing
Uma Thanigai Arasu et al.
Cellular and molecular life sciences : CMLS, 77(20), 4093-4115 (2019-12-11)
Intercellular communication is fundamental to the survival and maintenance of all multicellular systems, whereas dysregulation of communication pathways can drive cancer progression. Extracellular vesicles (EVs) are mediators of cell-to-cell communication that regulate a variety of cellular processes involved in tumor
Andreas Frøslev Mathisen et al.
Scientific reports, 14(1), 14669-14669 (2024-06-26)
Non-obese diabetes (NOD) mice are an established, spontaneous model of type 1 diabetes in which diabetes develops through insulitis. Using next-generation sequencing, coupled with pathway analysis, the molecular fingerprint of early insulitis was mapped in a cohort of mice ranging
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