G9003
D-谷氨酰胺
≥98% (HPLC)
别名:
D -谷氨酸5-酰胺, D-2-氨基戊二酸
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关于此项目
经验公式（希尔记法）:
C5H10N2O3
化学文摘社编号:
分子量:
146.14
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1723796
产品名称
D-谷氨酰胺, ≥98% (HPLC)
InChI
1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
SMILES string
N[C@H](CCC(N)=O)C(O)=O
InChI key
ZDXPYRJPNDTMRX-GSVOUGTGSA-N
assay
≥98% (HPLC)
form
powder
color
white
application(s)
cell analysis
Quality Level
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Application
D-谷氨酰胺已用于研究其在保护乙醛诱导的Caco-2细胞单层屏障功能破坏中的作用。
Biochem/physiol Actions
谷氨酰胺通过α-酮戊二酸和谷氨酸形成氨基酸转氨作用的中心代谢产物。这种氨基酸通过不同的酶代谢，例如存在于肝脏中的谷氨酰胺酶和存在于骨骼肌中的谷氨酰胺合成酶。在细胞质中由其他氨基酸产生，主要由支链氨基酸和谷氨酸产生。它在氨代谢和解毒中起着至关重要的作用。其骨骼肌水平在创伤、手术和炎症状态后显著降低。它可作为致命败血症的预后标志物，在此期间其骨骼肌水平降低了90%。
General description
谷氨酰胺是人体内存在的一种非必需的、最丰富的游离氨基酸。它是蛋白质的重要组成成分，是20种蛋白原氨基酸之一。它形成5-6%的结合氨基酸。
Other Notes
谷氨酰胺的非天然异构体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Smriti Shridhar et al.
Journal of biotechnology, 257, 13-21 (2017-03-18)
Chinese Hamster Ovary (CHO) cells are the preferred cell line for production of biopharmaceuticals. These cells are capable to grow without serum supplementation, but drastic changes in their phenotype occur during adaptation to protein-free growth, which typically include the change
Erich Roth
The Journal of nutrition, 138(10), 2025S-2031S (2008-09-23)
Glutamine is the most abundant free amino acid of the human body. Besides its role as a constituent of proteins and its importance in amino acid transamination, glutamine has regulatory capacity in immune and cell modulation. Glutamine deprivation reduces proliferation
A Seth et al.
American journal of physiology. Gastrointestinal and liver physiology, 287(3), G510-G517 (2004-08-28)
Role of L-glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function was evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a
Anna Ostrovskaya et al.
BMC cancer, 19(1), 157-157 (2019-02-20)
Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical importance. In this study we tested expression and performed
Indra Saptiama et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 25(18), 4843-4855 (2019-01-18)
The effective utilization of various biomolecules for creating a series of mesoporous boehmite (γ-AlOOH) and gamma-alumina (γ-Al2 O3 ) nanosheets with unique hierarchical multilayered structures is demonstrated. The nature and concentration of the biomolecules strongly influence the degree of the
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