G9048
GANT61
≥98% (HPLC)
别名:
2，2＆＃8242;-[[二氢-2-（4-吡啶基）-1，3-（2H，4H）-嘧啶二基]双（亚甲基）]双[N，N-二甲基苯胺, NSC 136476
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关于此项目
经验公式（希尔记法）:
C27H35N5
化学文摘社编号:
分子量:
429.60
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
产品名称
GANT61, ≥98% (HPLC)
SMILES string
N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C
InChI
1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
InChI key
KVQOGDQTWWCZFX-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >2 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
GANT61 是 Hh 信号通路 Gli 抑制剂。
GANT61 通过抑制 Gli1 的转录活性阻断 hedgehog 通路信号转导（IC50 =5 μM）。 在裸鼠中，GANT 61 可导致 22Rv1 人前列腺肿瘤细胞异种移植缩小。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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