G9137
Gly-Pro 4-甲氧基-β-萘酰胺
dipeptidylpeptidase IV substrate
别名:
H-Gly-Pro-4MbNA
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关于此项目
经验公式（希尔记法）:
C18H21N3O3
化学文摘社编号:
分子量:
327.38
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
产品名称
Gly-Pro 4-甲氧基-β-萘酰胺, dipeptidylpeptidase IV substrate
InChI
1S/C18H21N3O3/c1-24-16-10-13(9-12-5-2-3-6-14(12)16)20-18(23)15-7-4-8-21(15)17(22)11-19/h2-3,5-6,9-10,15H,4,7-8,11,19H2,1H3,(H,20,23)
SMILES string
COc1cc(NC(=O)C2CCCN2C(=O)CN)cc3ccccc13
InChI key
LSZPYDQEJZWJIJ-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Application
Gly-Pro 4-methoxy-β-naphthylamide has been used as a substrate to evaluate the dipeptidyl peptidase-4 (DPP4) enzymatic activity.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Substrates
Substrate for Dipeptidyl Aminopeptidase IV
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Gerd Luippold et al.
Diabetes research and clinical practice, 143, 199-203 (2018-07-22)
The two dipeptidyl peptidase (DPP)-4 inhibitors, linagliptin and sitagliptin, were shown to exert different binding kinetics in vitro. Twenty-four hours after oral dosing particularly in vivo inhibition of renal-specific DPP-4 activity was more sustained in Sprague Dawley rats after exposure
Wesley Mah et al.
The American journal of pathology, 187(8), 1717-1735 (2017-06-24)
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been
Anna-Lena Mayer et al.
British journal of pharmacology, 178(4), 878-895 (2020-11-11)
Dipeptidyl peptidase 4 (DPP-4) inhibitors are a class of oral glucose-lowering drugs used in the treatment of type 2 diabetes. In a pilot study using human kidney biopsies, we observed high DPP-4 expression in early crescent formation. This glomerular lesion
Wesley Mah et al.
The American journal of pathology, 187(8), 1717-1735 (2017-06-24)
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been
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