G9548
光甘草定
≥98% (HPLC), powder, isoflavan
别名:
4-[(3R)-3,4-二氢-8,8-二甲基-2H,8H-苯并 [1,2-b:3,4-b′] 二吡喃-3-基]-1,3-苯二酚, 光甘草定, (R)-4-（3,4-二氢-8,8-二甲基-2 H,8 H-苯并 [1,2-b:3,4-b′] 二吡喃-3-基）-1,3-苯二酚
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关于此项目
经验公式（希尔记法）:
C20H20O4
化学文摘社编号:
分子量:
324.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
7141956
产品名称
光甘草定, ≥98% (HPLC), powder
InChI
1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
SMILES string
CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c4ccc(O)cc4O
InChI key
LBQIJVLKGVZRIW-ZDUSSCGKSA-N
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
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相关类别
Application
光甘草定已被用于：
- 分析其在健康志愿者血浆中的转甲状腺素蛋白（TTR）稳定作用
- 作为质子核磁共振（1H NMR）中的标准品用于通过多光谱和分子对接（multi-spectroscopic and molecular docking ）技术研究光甘草定和人血清球蛋白的相互作用
- 研究其对核苷酸结合寡聚化结构域样受体Pyrin域蛋白3（NLRP3）炎症小体活化的作用
Biochem/physiol Actions
光甘草定是glavonoid 的主要成分，也称为来源于甘草的黄酮油，是用于传统医学和草药的天然增补剂。
光甘草定是一种可生物利用的异黄烷，是从甘草（洋甘草 ）根部提取物分离而来。据报道光甘草定具有多种生物活性，包括强抗氧化活性、 抗 LDL 氧化活性、抗-幽门螺旋杆菌性质、类雌激素活性和自由基清除活性。 它也可以抑制血清素再摄取、黑素生成、发炎和细胞色素P450、3A4、2B6和2C9。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
H-S Kwon et al.
Clinical and experimental immunology, 151(1), 165-173 (2007-11-17)
Inflammatory bowel disease (IBD) is characterized by detrimental immune reactivity in the gut, and the imbalance between proinflammatory and anti-inflammatory reactivity. The aims of this study were to determine whether oral administration of glabridin, a functional component of liquorice, could
Hiroaki Matsushita et al.
Heliyon, 7(10), e08101-e08101 (2021-10-26)
Transthyretin (TTR) is an amyloidogenic protein associated with hereditary and nonhereditary transthyretin amyloidoses (ATTR). Dissociation of the tetramer of TTR to the monomer induces TTR misfolding, which leads to amyloid fibril formation and triggers the onset of ATTR amyloidosis. Stabilizers
A novel fluorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors
Ye Y, et al.
Sensors and Actuators B, Chemical, 301, 126864-126864 (2019)
Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans.
Fumiki Aoki et al.
Journal of the American College of Nutrition, 26(3), 209-218 (2007-07-20)
Licorice flavonoids have various physiological activities such as abdominal fat-lowering, hypoglycemic and antioxidant effects. Licorice flavonoid oil (LFO: Kaneka Glavonoid Rich Oil) is a new dietary ingredient containing licorice flavonoids dissolved in medium-chain triglycerides (MCT). Glabridin is one of the
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin
Razzak MA, et al.
Food Hydrocolloids, 91, 290-300 (2019)
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