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G9548

光甘草定

Name: 光甘草定
Brand: SIGMA

≥98% (HPLC), powder, isoflavan

别名:

4-[(3R)-3,4-二氢-8,8-二甲基-2H,8H-苯并 [1,2-b:3,4-b′] 二吡喃-3-基]-1,3-苯二酚, 光甘草定, (R)-4-（3,4-二氢-8,8-二甲基-2 H,8 H-苯并 [1,2-b:3,4-b′] 二吡喃-3-基）-1,3-苯二酚

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₀O₄

化学文摘社编号:

59870-68-7

分子量:

324.37

NACRES:

NA.77

PubChem Substance ID:

329799990

UNSPSC Code:

12352200

MDL number:

MFCD03427694

Beilstein/REAXYS Number:

7141956

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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产品名称

光甘草定, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c4ccc(O)cc4O

InChI

1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1

InChI key

LBQIJVLKGVZRIW-ZDUSSCGKSA-N

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Application

光甘草定已被用于：

分析其在健康志愿者血浆中的转甲状腺素蛋白（TTR）稳定作用
作为质子核磁共振（1H NMR）中的标准品用于通过多光谱和分子对接（multi-spectroscopic and molecular docking ）技术研究光甘草定和人血清球蛋白的相互作用
研究其对核苷酸结合寡聚化结构域样受体Pyrin域蛋白3（NLRP3）炎症小体活化的作用

Biochem/physiol Actions

光甘草定是glavonoid 的主要成分，也称为来源于甘草的黄酮油，是用于传统医学和草药的天然增补剂。

光甘草定是一种可生物利用的异黄烷，是从甘草（洋甘草 ）根部提取物分离而来。据报道光甘草定具有多种生物活性，包括强抗氧化活性、抗 LDL 氧化活性、抗-幽门螺旋杆菌性质、类雌激素活性和自由基清除活性。它也可以抑制血清素再摄取、黑素生成、发炎和细胞色素P450、3A4、2B6和2C9。

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000511888

0000335709

0000481446

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Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans.

Fumiki Aoki et al.

Journal of the American College of Nutrition, 26(3), 209-218 (2007-07-20)

Licorice flavonoids have various physiological activities such as abdominal fat-lowering, hypoglycemic and antioxidant effects. Licorice flavonoid oil (LFO: Kaneka Glavonoid Rich Oil) is a new dietary ingredient containing licorice flavonoids dissolved in medium-chain triglycerides (MCT). Glabridin is one of the

Glavonoid, a possible supplement for prevention of ATTR amyloidosis.

Hiroaki Matsushita et al.

Heliyon, 7(10), e08101-e08101 (2021-10-26)

Transthyretin (TTR) is an amyloidogenic protein associated with hereditary and nonhereditary transthyretin amyloidoses (ATTR). Dissociation of the tetramer of TTR to the monomer induces TTR misfolding, which leads to amyloid fibril formation and triggers the onset of ATTR amyloidosis. Stabilizers

A novel fluorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors

Ye Y, et al.

Sensors and Actuators B, Chemical, 301, 126864-126864 (2019)

Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin

Razzak MA, et al.

Food Hydrocolloids, 91, 290-300 (2019)

Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress.

Itamar Yehuda et al.

Phytotherapy research : PTR, 25(5), 659-667 (2010-11-06)

The risk of death from cardiovascular diseases (CVDs), which are exacerbated by oxidative stress, is higher in diabetic women. This phenomenon has been attributed to the loss of estradiol-vascular protection. Such knowledge led us to examine the potential of glabridin

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全球贸易项目编号

货号	GTIN
G9548-5MG	04061832722528
G9548-25MG	04061833650301

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