γ-Globulin molecules is made up of four polypeptide chains, of which two have molecular weights of about 50,000 and two of about 20,000. These chains are cross-linked by disulfide bonds.

γ-Globulins from sheep were used to study the influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. It was used in a study to test the interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues. It was also used in a study to test the enhanced progesterone and testosterone secretion, and depressed estradiol secretion in vitro from small white follicle cells of incubating turkey hens.

Prepared from Cohn Fraction II, III