G9893
Gliotoxin
from Gliocladium fimbriatum, ≥98% (HPLC), powder, immunomodulating agent
别名:
Aspergillin
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关于此项目
经验公式（希尔记法）:
C13H14N2O4S2
化学文摘社编号:
分子量:
326.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
50675
MDL number:
产品名称
胶霉毒素 来源于胶霉,
SMILES string
CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
InChI key
FIVPIPIDMRVLAY-RBJBARPLSA-N
InChI
1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
Quality Level
General description
Chemical structure: epipolythiodioxopiperazine
Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.
Application
Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.
Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro.
Biochem/physiol Actions
Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
On the cytotoxicity of some microbial volatile organic compounds as studied in the human lung cell line A549
Kreja L and Seidel HJ
Chemosphere, 49(1), 105 -1110 (2002)
Aspergillus mycotoxins and their effect on the host
Kamei K and Watanabe A
Medical Mycology, 43(sup1), 95 -999 (2005)
Gliotoxin and related epipolythiodioxopiperazines
Waring P and Beaver J
General Pharmacology, 27(8), 1311-1316 (1996)
Detection of gliotoxin in experimental and human aspergillosis
Lewis RE, et al.
Infection and Immunity, 73(1), 635 -6637 (2005)
Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
Stanzani M, et al.
Blood, 105(6), 2258 -22265 (2005)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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