G9893
Gliotoxin
from Gliocladium fimbriatum, ≥98% (HPLC), powder, immunomodulating agent
别名:
Aspergillin
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关于此项目
经验公式（希尔记法）:
C13H14N2O4S2
化学文摘社编号:
分子量:
326.39
Beilstein:
50675
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
胶霉毒素 来源于胶霉,
质量水平
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
InChI
1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChI key
FIVPIPIDMRVLAY-RBJBARPLSA-N
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一般描述
Chemical structure: epipolythiodioxopiperazine
Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.
应用
Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.
Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro.
生化/生理作用
Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes
Stanzani M, et al.
Blood, 105(6), 2258 -22265 (2005)
Detection of gliotoxin in experimental and human aspergillosis
Lewis RE, et al.
Infection and Immunity, 73(1), 635 -6637 (2005)
On the cytotoxicity of some microbial volatile organic compounds as studied in the human lung cell line A549
Kreja L and Seidel HJ
Chemosphere, 49(1), 105 -1110 (2002)
Aspergillus mycotoxins and their effect on the host
Kamei K and Watanabe A
Medical Mycology, 43(sup1), 95 -999 (2005)
Gliotoxin and related epipolythiodioxopiperazines
Waring P and Beaver J
General Pharmacology, 27(8), 1311-1316 (1996)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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