Merck
CN

G9910

Sigma-Aldrich

脱氧甘胆酸钠

BioXtra, ≥97% (HPLC)

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别名:
3α,12α--二羟基-5β-胆烷-24-油酸 N-(羧甲基)酰胺, N-(3α,12α-二羟基-24-氧胆烷-24-基)甘氨酸, 甘氨脱氧胆酸, 脱氧甘胆酸 钠盐
经验公式(希尔记法):
C26H42NNaO5
CAS号:
分子量:
471.61
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.25

描述

anionic

质量水平

产品线

BioXtra

检测方案

≥97% (HPLC)

分子量

471.61 g/mol

杂质

≤0.0025% Phosphorus (P)
≤0.1% Insoluble matter

CMC

2.1 mM

溶解性

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

痕量阴离子

chloride (Cl-): ≤1%
sulfate (SO42-): ≤0.05%

痕量阳离子

Al: ≤0.0005%
Ca: ≤0.011%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.003%

SMILES字符串

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

InChI key

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

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一般描述

甘氨酸胆酸钠是一种胆汁盐,可用于形成生物模拟环境。

应用

甘氨酸乙氧基胆酸钠已被用于一项开发比混合胆汁盐系统(MBS)更能模拟肠液的生理液体的研究中。 它还被用于研究胆盐胶束的Ca2+缓冲能力。

生化/生理作用

在肝脏细胞中诱导凋亡;可能诱导DNA断裂。

其他说明

胆盐

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids
Huda H Zughaid, et al.
International Journal of Pharmaceutics, 422, 7-7 (2012)
Raina Thakur et al.
Photochemistry and photobiology, 88(5), 1248-1255 (2012-05-23)
Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Experimental results demonstrate that photophysical enhancement and fall of a particular prototropic species are sensitive
Domenico Trombetta et al.
Nutrients, 12(11) (2020-11-11)
Almond kernels contain phytochemicals with positive health effects in relation to heart disease, diabetes and obesity. Several studies have previously highlighted that almond cell wall encapsulation during digestion and particle size are factors associated with these benefits. In the present
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Food & function, 8(4), 1599-1610 (2017-03-16)
Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative

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