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Merck
CN

G9923

胡黄连苷I

≥98% (HPLC)

别名:

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside 6-[(2E)-3-phenyl-2-propenoate], 6′-Cinnamoylcatalpol

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关于此项目

经验公式（希尔记法）:
C24H28O11
化学文摘社编号:
27409-30-9
分子量:
492.47
UNSPSC Code:
12352205
MDL number:
MFCD29505480
NACRES:
NA.25
EC Number:
248-445-1

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InChI key

XZGPUOQGERGURE-LUVHZPKESA-N

InChI

1S/C24H28O11/c25-11-24-16-13(17(27)21(24)35-24)8-9-31-22(16)34-23-20(30)19(29)18(28)14(33-23)10-32-15(26)7-6-12-4-2-1-3-5-12/h1-9,13-14,16-23,25,27-30H,10-11H2/b7-6+/t13-,14-,16-,17+,18-,19+,20-,21+,22+,23+,24-/m1/s1

SMILES string

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(/C=C/C2=CC=CC=C2)=O)O[C@H]1O[C@@H]3OC=C[C@]4([H])[C@@]3([H])[C@](O5)(CO)[C@@H]5[C@H]4O

assay

≥98% (HPLC)

solubility

ethanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

Quality Level

200

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相关类别

General description

Picroside I is one of the major phytochemicals found in the roots and rhizomes of Picrorhiza kurroa Royle ex Benth.

Biochem/physiol Actions

Phytochemical found within a Traditional Chinese Medicine herbal preparation. Picroside I, an iridoid glycoside, is a hepatoprotective agent.
Picroside I is a potent anti-cancer, antioxidant, and anti-inflammatory agent. Picroliv is a standardized drug that is a mixture of two iridoid glycoside components picroside I and picroside II (Kutkoside). It displays protection against ischemia-reperfusion injury, respiratory, and inflammatory diseases.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000224552
SLCQ4414
0000224552
SLBN3608V
SLBC6345V

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M L Brown
AANA journal, 60(1), 33-40 (1992-02-01)
A prospective study was undertaken in an effort to determine the usefulness of the end-tidal carbon dioxide monitor in detecting anesthesia-related critical incidents. The critical incident technique was employed in the evaluation of 2,334 anesthetics. Anesthesia providers completed a critical
P Li et al.
Biological & pharmaceutical bulletin, 23(7), 890-892 (2000-08-05)
A crude methanol extract of Picrorhizae Rhizoma, the dried underground parts of Picrorhiza scrophulariiflora PENNELL, has been shown to potentiate the nerve growth factor (NGF)-induced neurite outgrowth from PC12D cells. The methanol extract was partitioned between ethyl acetate and water.
Harsharan Singh et al.
Gene, 515(2), 320-328 (2012-12-15)
Picrorhiza kurrooa Royle ex Benth. is an economically important medicinal plant known to yield picrosides which have high medicinal value. Picroside I and picroside II are major picrosides associated with various bioactivities. The present work analyzed the expression of various
P Li et al.
European journal of pharmacology, 406(2), 203-208 (2000-10-06)
Natural iridoid, picroside I (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1, 2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate)) or II (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-[(4-hydroxy-3-methoxybenzoyl)oxy]-1a-(hydroxymethyl )ox ireno[4,5]cyclopenta[1,2-c]pyran-2-yl) alone did not exhibit neuritogenic activity, but caused a concentration-dependent (>0.1 microM) enhancement of nerve growth factor (NGF, 2 ng/ml)-induced neurite outgrowth from PC12D
Pamita Bhandari et al.
Journal of chromatography. A, 1194(2), 257-261 (2008-05-21)
Sugars play a critical role in regulating overall cellular metabolism in high altitude growing plants. These plants are shown to have high levels of sugars to enhance their tolerance to abiotic stresses such as drought and freezing temperature. In the
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