ligand
recombinant protein A (E. coli)
packaging
pack of 200 mL
manufacturer/tradename
Cytiva 17-5269-02
storage condition
(20% Ehtanol)
matrix
highly cross-linked agarose
avg. part. size
75 (d₅₀v is the median particle size of the cumulative volume distribution)
cleaning in place
2-12
working range
3-10
capacity
≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)
suitability
suitable for bioprocess medium
storage temp.
2-8°C
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General description
Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
MabSelect™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.
Application
MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion Proteins.
The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.
MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.
The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.
MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.
Features and Benefits
- Higher dynamic binding capacity than currently available Protein A chromatography media.
- Improved process economics through reduced raw materials costs and/or reduced number of cycles
- High purity capture due to high ligand selectivity and matrix hydrophilicity
- Slightly lower pressure/fLow properties compared to MabSelect™ SuRe™ and MabSelect
Preparation Note
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
Analysis Note
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
Legal Information
MabSelect is a trademark of Cytiva
SuRe is a trademark of Cytiva
signalword
Warning
hcodes
存储类别
3 - Flammable liquids
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This page describes efficient column packing and preparation for affinity chromatography of antibodies.
本页介绍了高效的色谱柱填充和抗体亲和层析的制备。
相关内容
在分析之前，可以应用多种化学和物理纯化方法分离或浓缩目标分析物，有助于将样品制成与分析技术相兼容的形式，降低样品复杂性，去除干扰杂质，并在分析之前浓缩分析物。
Purification methods for downstream analysis reduce sample complexity, remove interferences, and concentrate analytes for more accurate results.
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