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Merck
CN

GE17-5269-02

MabSelect™ Xtra

Cytiva 17-5269-02, pack of 200 mL

别名:

affinity resin, chromatography resin, gel, mAb purification resin, matrix, protein A resin

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UNSPSC代码:
41106500
NACRES:
NA.56

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ligand

recombinant protein A (E. coli)

包装

pack of 200 mL

制造商/商品名称

Cytiva 17-5269-02

储存条件

(20% Ehtanol)

基质

highly cross-linked agarose

平均零件尺寸

75 (d₅₀v is the median particle size of the cumulative volume distribution)

cleaning in place

2-12

工作范围

3-10

容量

≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)

适用性

suitable for bioprocess medium

储存温度

2-8°C

相关类别

一般描述

Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
MabSelect™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.

应用

MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion Proteins.

The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.

特点和优势

  • Higher dynamic binding capacity than currently available Protein A chromatography media.
  • Improved process economics through reduced raw materials costs and/or reduced number of cycles
  • High purity capture due to high ligand selectivity and matrix hydrophilicity
  • Slightly lower pressure/fLow properties compared to MabSelect™ SuRe™ and MabSelect

制备说明

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.

分析说明

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

法律信息

MabSelect is a trademark of Cytiva
SuRe is a trademark of Cytiva

象形图

Flame
GHS02

警示用语：

Warning

危险声明

H226

储存分类代码

3 - Flammable liquids

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商品

Column Packing and Preparation for Affinity Chromatography of Antibodies

This page describes efficient column packing and preparation for affinity chromatography of antibodies.

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