form
solid
feature
wetted part: no
packaging
pack of 100 g
manufacturer/tradename
Cytiva RPN6301
color
White
pH range
5-7
solubility
cold water: soluble (Soluble in cold water and hot water), diethyl ether: soluble (Partially soluble in diethyl ether), methanol: soluble (Easily soluble in methanol)
General description
Thiourea is a chaotrope used together with urea in the IPG strip rehydration to solubilize and denature proteins, and improve the solubility of membrane proteins.
Application
Thiourea has been used as a component of lysis buffer for solubilization of the proteins from tissue samples and T-leukemia cells. It has also been used as a component of sample buffer for placental tissue, leaf proteome, and 2D electrophoresis.
Biochem/physiol Actions
Thiourea is an organic compound and its derivatives have antibacterial, antiviral, antifungal and insecticidal property. It is actively used in the drug development against human immunodeficiency virus (HIV) and hepatitis C infection. Thiourea inhibits cyclooxygenase enzyme and effectively reduces prostaglandin E2 (PGE2) and thromboxane (TXB2) production and is antithrombotic in human platelets. It is cytotoxic to vaginal epithelial cells and may function as potent spermicidal agent. Thiourea based derivatives of anticancer drug sorafenib, eliclits antiproliferative activity in human colon cancer cell line, HCT116 cells.
Preparation Note
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
Analysis Note
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
signalword
Warning
hcodes
存储类别
13 - Non Combustible Solids
法规信息
新产品
此项目有
Synthesis and antiplatelet activity of antithrombotic thiourea compounds: biological and structure-activity relationship studies
Lourencco A, et al.
Molecules (Basel), 20(4), 7174-7200 (2015)
Novel thiourea compounds as dual-function microbicides
D?Cruz, OJ, et al.
Biology of Reproduction, 63(1), 196-205 (2000)
Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells
Li J, et al.
Autophagy, 6(6), 711-724 (2010)
Spontaneous Unexplained Preterm Labor with Intact Membrane: Finding Protein Biomarkers through Placenta Proteome
Electrophoresis-Life Sciences Practical Applications (2018)
Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents
Yao J, et al.
Bioorganic & Medicinal Chemistry, 20(9), 2923-2929 (2012)
商品
This page describes components of rehydration solutions for use in 2-D Electrophoresis with Cytiva products.
实验方案
This page describes typical rehydration solutions for use in gel electrophoresis with Cytiva products.
This page describes two-dimensional separation of protein samples with Cytiva products.
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