Immunogen Sequence: GI # 4503175, sequence 6-41

Recombinant chemokine (C-X-C motif) receptor 4 isoform b

Anti-CXCR4 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

C-X-C chemokine receptor type 4 (CXCR-4) is a protein encoded by the CXCR4 gene in humans. It is expressed in various cell types and the mechanisms involved in the regulation of its expression are still unknown. CXCR4 is a cofactor for fusion and entry of T cell-tropic strains of HIV-1. It is a chemokine receptor that is overexpressed in certain cancer types and involved in migration toward distant organs. CXCR4 is associated with various functions such as embryo organogenesis, immunological functions and T lymphocyte trafficking. High CXCR4 expression can be helpful in predicting clear-cell renal cell carcinoma (ccRCC). It plays a vital role in modulating cell trafficking in hematopoietic stem cells and clonal B cells. CXCR4 plays an important role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. It is an efficient prognostic factor for breast cancer.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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