GW21169
Anti-APAF1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Apoptotic protease-activating factor 1
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
manufacturer/tradename
Genway 15-288-21169
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... APAF1(317)
Immunogen
Immunogen Sequence: GI # 32483361, sequence 307-388
Recombinant apoptotic protease activating factor isoform d
Application
Anti-APAF1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Apoptotic protease activating factor 1 is a human homolog of C. elegans CED-4 gene and is a key regulator gene of apoptosis. It acts as a central component of the intrinsic pathway of apoptosis. Loss of APAF-1 expression is involved with chemorefractory malignant melanoma and neuronal cell differentiation. Over expression of this gene is related to an undifferentiated state in the testicular germ cell tumor (TGCT) pathway and is involved in carcinogenesis of germ cell tumors. APAF-1, when bound to cytochrome c, may trigger the activation of caspase-3 leading to apoptosis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Shucheng Gu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(3), 2211-2218 (2013-10-22)
Apoptotic protease-activating factor 1 (APAF-1) is a central component of the intrinsic pathway of apoptosis. Our study aims at searching the role of APAF-1 in iron overload myelodysplastic syndrome (MDS). Erythroid apoptosis rate, mRNA expression levels of APAF-1, and caspase-9
Reza Behjati et al.
Cancer science, 102(1), 267-274 (2010-10-28)
Apoptotic protease activating factor-1 (APAF-1) is a key regulator gene of apoptosis, located downstream from p53. Loss of APAF-1 expression is associated with chemorefractory malignant melanoma and neuronal cell differentiation. In order to make clear the function of APAF-1 in
H Zou et al.
Cell, 90(3), 405-413 (1997-08-08)
We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3. The NH2-terminal 85 amino acids of Apaf-1 show 21% identity and 53%
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