biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
manufacturer/tradename
Genway 15-288-21181
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KDR(3791)
Immunogen
Immunogen Sequence: GI # 9087218, sequence 51-119
Recombinant vascular endothelial growth factor receptor 2
Application
Anti-VEGFR-2 antibody produced in chicken is suitable for immunohistochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase, VEGFR-2) is a VEGF receptor and is encoded by KDR gene in humans. It plays a crutial role in controlling endothelial trafficking activity and is involved in phosphotyrosine phosphatase 1b (PTP1b). PTP1b acts as a key regulator of endothelial VEGFR2 signaling and plays a critical role in regulation of the extent of vascular tree formation. VEGFR2 may be associated with gout and hyperuricaemia risks in Malays.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Soumaya Hachana et al.
British journal of pharmacology, 177(9), 1949-1966 (2019-12-29)
Age-related macular degeneration (AMD) is a complex neurodegenerative disease treated by anti-VEGF intravitreal injections. As inflammation is potentially involved in retinal degeneration, the pro-inflammatory kallikrein-kinin system is a possible alternative pharmacological target. Here, we investigated the effects of anti-VEGF and
PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.
Lanahan AA, Lech D, Dubrac A, et al.
Circulation, 130(11), 902-909 (2014)
Yap W K Roseline et al.
Malaysian journal of nutrition, 18(3), 307-317 (2012-12-01)
Gout and hyperuricaemia attributed to genetic and lifestyle factors have been associated with several chronic diseases. This study aimed to determine the association and interaction effects between vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377 and rs2071559) and dietary
Giuseppe Di Stolfo et al.
Clinical hemorheology and microcirculation, 72(1), 23-38 (2018-10-16)
Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells
Soumaya Hachana et al.
British journal of pharmacology, 175(6), 968-983 (2017-12-30)
The kinin B1 receptor contributes to vascular inflammation and blood-retinal barrier breakdown in diabetic retinopathy (DR). We investigated the changes in expression, cellular localization and vascular inflammatory effect of B1 receptors in retina of streptozotocin diabetic rats. The distribution of
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