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Merck
CN

GW21444

Anti-M6PR antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Cation-dependent mannose-6-phosphate receptor

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Citations:
6
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biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

manufacturer/tradename

Genway 15-288-21444

technique(s)

immunocytochemistry: suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... M6PR(4074)

Immunogen

Immunogen Sequence: GI # 4505061, sequence 60-114
Recombinant cation-dependent mannose-6-phosphate receptor

Application

Anti-M6PR antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Mannose 6-phosphate receptor is an integral transmembrane glycoprotein encoded by the M6PR gene in humans. It is ubiquitously expressed and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. It is a 46kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and plays a key role in the delivery of lysosomal enzymes to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and diverting them from the secretory pathway. M6PR plays a major role in cellular function by transporting Man-6-P-containing acid hydrolases from the Golgi to endosomal/lysosomal compartments.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
低风险生物材料
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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G G Sahagian et al.
The Journal of biological chemistry, 260(17), 9838-9842 (1985-08-15)
The mannose 6-phosphate (Man-6-P) receptor is an integral membrane glycoprotein which mediates intracellular transport and receptor-mediated endocytosis of lysosomal proteins. Clathrin-coated vesicles, which have been shown to be significantly involved in these processes, have also been shown to be a
Shelby C Bearrows et al.
Journal of cell science, 132(13) (2019-06-12)
Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to regulate granule biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are
Linda J Olson et al.
Biochemistry, 49(1), 236-246 (2009-11-26)
The 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) plays a key role in the delivery of lysosomal enzymes to the lysosome by binding newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and diverting them from the secretory pathway. Previous studies on
Seii Ohka et al.
Biology open, 11(9) (2022-08-06)
Enterovirus 71 (EV71) is one of the causative agents of hand-foot-and-mouth disease, which in some circumstances could lead to severe neurological diseases. Despite of its importance for human health, little is known about the early stages of EV71 infection. EV71
Nancy M Dahms et al.
Glycobiology, 18(9), 664-678 (2008-07-16)
The two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by

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