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H0292

HIV-1 Tat Peptide

Name: HIV-1 Tat Peptide
Brand: SIGMA

≥97% (HPLC), lyophilized powder

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关于此项目

经验公式（希尔记法）:

C₆₄H₁₁₈N₃₂O₁₄

化学文摘社编号:

191936-91-1

分子量:

1559.83

UNSPSC Code:

12352202

PubChem Substance ID:

329815111

NACRES:

NA.32

MDL number:

MFCD07366706

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属性

产品名称

HIV-1 Tat Protein (47-57),

biological source

synthetic

Quality Level

200

form

lyophilized powder

solubility

deionized water: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C64H118N32O14/c65-25-3-1-11-39(89-50(101)38(13-5-27-81-59(69)70)88-48(99)34-87-49(100)37(67)33-35-19-21-36(97)22-20-35)51(102)90-40(12-2-4-26-66)52(103)91-41(14-6-28-82-60(71)72)53(104)92-43(16-8-30-84-62(75)76)55(106)95-45(23-24-47(68)98)57(108)94-42(15-7-29-83-61(73)74)54(105)93-44(17-9-31-85-63(77)78)56(107)96-46(58(109)110)18-10-32-86-64(79)80/h19-22,37-46,97H,1-18,23-34,65-67H2,(H2,68,98)(H,87,100)(H,88,99)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H,94,108)(H,95,106)(H,96,107)(H,109,110)(H4,69,70,81)(H4,71,72,82)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

InChI key

RAVVEEJGALCVIN-AGVBWZICSA-N

说明

General description

HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule.

Biochem/physiol Actions

Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

存储类别

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein

Charnay N, et al.

Retrovirology, 6(1), 74-74 (2009)

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?

Campbell GR and Loret EP

Retrovirology, 6(1), 50-50 (2009)

The HIV-1 Tat protein enhances splicing at the major splice donor site

Mueller N, et al.

Journal of Virology, 92(14), e01855-e01817 (2018)

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