H0500
1,2,3,4-四氢哈尔满-3-羧酸
别名:
1-甲基-1,2,3,4-四氢-β-咔啉-3-羧酸
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关于此项目
经验公式（希尔记法）:
C13H14N2O2
化学文摘社编号:
分子量:
230.26
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI key
ZUPHXNBLQCSEIA-UHFFFAOYSA-N
SMILES string
CC1NC(Cc2c1[nH]c3ccccc23)C(O)=O
InChI
1S/C13H14N2O2/c1-7-12-9(6-11(14-7)13(16)17)8-4-2-3-5-10(8)15-12/h2-5,7,11,14-15H,6H2,1H3,(H,16,17)
storage temp.
−20°C
Quality Level
Application
Reactant involved in synthesis of molecules for biological studies including:
- Cytotoxicity and insecticidal activities of harmine derivatives
- Isoquinolines, β-carbolines, and 3-deazapurines via oxidative decarboxylation
- Cytotoxic evaluation of 1,3-di- and 1,3,9-trisubstituted β-carbolines
Biochem/physiol Actions
在与 L-色氨酸摄取相关的嗜酸性粒细胞增多-肌痛综合征中存在牵连。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K Fujie et al.
Mutation research, 240(4), 281-288 (1990-04-01)
The acute cytogenetic effects of tyramine and MTCAs, precursors of the mutagen present in soy sauce, were studied with the in vivo chromosome aberration test in rat bone marrow cells. The chemicals were administered intraperitoneally. Statistically significant positive results were
S Manabe et al.
Experimental eye research, 63(2), 179-186 (1996-08-01)
A fluorescent beta-carboline, 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid (MTCA) was identified in human normal lenses and cataractous lenses. The mean total amounts of MTCA in normal lenses (n = 7), diabetic cataractous lenses (n = 15), and senile cataractous lenses (n =
J Adachi et al.
Archives of toxicology, 65(6), 505-509 (1991-01-01)
1-Methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) is now thought to be a possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. In the present study a factor affecting endogenous formation of MTCA in 32 healthy men is studied. Urinary excretions of
Y Yamaguchi et al.
Biochemical and biophysical research communications, 178(3), 1008-1013 (1991-08-15)
While the pathogenesis of eosinophilia-myalgia syndrome (EMS) remains obscure, the ingestion of L-trypophan (LT) and possibly certain constituents in the LT product might be associated. We investigated the effect of chemically synthesized substances, 1,1'-ethylidene bis[tryptophan] (EBT) and its decomposition product
B Gutsche et al.
Journal of chromatography. A, 767(1-2), 101-106 (1997-04-11)
A rapid and sensitive method is described for the detection of 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, 1-methyl-1,2,3,4- tetrahydro-beta-carboline-3-carboxylic acid and 1-methyl-1,2,3,4-tetrahydro-beta-carboline by electrospray ionization tandem mass spectrometry coupled to liquid chromatography. In combination with selected reaction monitoring (SRM) detection limits of 3 ng
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