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Merck
CN

H0879

溴化已烷双胺

nAChR antagonist

别名:

N,N,N,N′,N′,N′-六甲基六亚甲基二溴铵, 己烷-1,6-双（三甲基溴化铵）

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关于此项目

线性分子式:
(CH3)3N(Br)(CH2)6N(Br)(CH3)3
化学文摘社编号:
55-97-0
分子量:
362.19
NACRES:
NA.77
PubChem Substance ID:
24278459
UNSPSC Code:
12352200
EC Number:
200-249-7
MDL number:
MFCD00011787
Beilstein/REAXYS Number:
3715749

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产品名称

溴化已烷双胺,

InChI

1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

InChI key

FAPSXSAPXXJTOU-UHFFFAOYSA-L

SMILES string

[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C

mp

282-285 °C (dec.)

Quality Level

200

Gene Information

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

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相关类别

Application

溴化六甲铵已用于：
  • 作为自主神经节阻断剂，研究其对大鼠胡须运动的影响
  • 作为烟碱受体拮抗剂，研究其对小鼠抗原诱导关节炎(AIA)进展的影响
  • 作为非选择性神经节烟碱型乙酰胆碱受体(nAChR)拮抗剂，研究其对小鼠中金雀花碱诱导的自主心血管反应的影响

Biochem/physiol Actions

溴化六甲铵是针对烟碱型乙酰胆碱受体(nAChR)的拮抗剂。它优先阻断自主神经节上的烟碱受体，只有在高剂量时才能穿过血脑屏障。

Features and Benefits

该化合物在《受体分类和信号转导手册》的 乙酰胆碱受体（烟酸） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP0115
BCCN3394
0000447824
0000447824
BCCM9695

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