H116
6-羟基多巴胺 氢溴酸盐
contains ascorbic acid as stabilizer, ≥98% (HPLC)
别名:
2-（2，4，5-三羟基苯基）乙胺 氢溴酸盐, 2，4，5-三羟基苯乙胺 氢溴酸盐, 2，5-二羟基酪胺 氢溴酸盐, 6 -羟基多巴胺
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关于此项目
线性分子式:
(HO)3C6H2CH2CH2NH2 · HBr
化学文摘社编号:
分子量:
250.09
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
211-247-0
Beilstein/REAXYS Number:
3713280
MDL number:
InChI key
MLACDGUOKDOLGC-UHFFFAOYSA-N
InChI
1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
SMILES string
Br.NCCc1cc(O)c(O)cc1O
assay
≥98% (HPLC)
contains
ascorbic acid as stabilizer
storage temp.
−20°C
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General description
方便、稳定地制备多巴胺能神经毒素，6-羟基多巴胺。
溶液应新鲜制备，并且应避光。
Preparation Note
每 5mg 小瓶加入 2mL 缓冲液，得到含有 10mM 6-羟基多巴胺和 0.01％（w/v）抗坏血酸的溶液。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
William Menegas et al.
Nature neuroscience, 21(10), 1421-1430 (2018-09-05)
Midbrain dopamine neurons are well known for their role in reward-based reinforcement learning. We found that the activity of dopamine axons in the posterior tail of the striatum (TS) scaled with the novelty and intensity of external stimuli, but did
Woori Kim et al.
Neurobiology of aging, 35(7), 1712-1721 (2014-02-25)
Dopamine (DA) neurons in sporadic Parkinson's disease (PD) display dysregulated gene expression networks and signaling pathways that are implicated in PD pathogenesis. Micro (mi)RNAs are regulators of gene expression, which could be involved in neurodegenerative diseases. We determined the miRNA
Julio C Tobón-Velasco et al.
Toxicology, 304, 109-119 (2013-01-01)
6-Hydroxydopamine (6-OHDA) is a neurotoxin that generates an experimental model of Parkinson's disease in rodents and is commonly employed to induce a lesion in dopaminergic pathways. The characterization of those molecular mechanisms linked to 6-OHDA-induced early toxicity is needed to
Ana Freitas et al.
Antioxidants (Basel, Switzerland), 10(7) (2021-08-07)
Parkinson's disease's etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has
Xinrong Li et al.
International journal of molecular medicine, 47(4) (2021-03-03)
Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). In a previous study, the authors demonstrated that ferritin heavy chain 1 (FTH1) inhibited ferroptosis in a model of 6‑hydroxydopamine
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