Merck
CN

H116

Sigma-Aldrich

6-羟基多巴胺 氢溴酸盐

contains ascorbic acid as stabilizer, ≥98% (HPLC)

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别名:
2-(2,4,5-三羟基苯基)乙胺 氢溴酸盐, 2,4,5-三羟基苯乙胺 氢溴酸盐, 2,5-二羟基酪胺 氢溴酸盐, 6 -羟基多巴胺
线性分子式:
(HO)3C6H2CH2CH2NH2 · HBr
CAS号:
分子量:
250.09
Beilstein:
3713280
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

检测方案

≥98% (HPLC)

包含

ascorbic acid as stabilizer

mp

216-220 °C (lit.)

储存温度

−20°C

SMILES string

Br.NCCc1cc(O)c(O)cc1O

InChI

1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H

InChI key

MLACDGUOKDOLGC-UHFFFAOYSA-N

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一般描述

方便、稳定地制备多巴胺能神经毒素,6-羟基多巴胺。
溶液应新鲜制备,并且应避光。

重悬

每 5mg 小瓶加入 2mL 缓冲液,得到含有 10mM 6-羟基多巴胺和 0.01%(w/v)抗坏血酸的溶液。

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Neurobiology of aging, 35(7), 1712-1721 (2014-02-25)
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Midbrain dopamine neurons are well known for their role in reward-based reinforcement learning. We found that the activity of dopamine axons in the posterior tail of the striatum (TS) scaled with the novelty and intensity of external stimuli, but did
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6-Hydroxydopamine (6-OHDA) is a neurotoxin that generates an experimental model of Parkinson's disease in rodents and is commonly employed to induce a lesion in dopaminergic pathways. The characterization of those molecular mechanisms linked to 6-OHDA-induced early toxicity is needed to
Ana Freitas et al.
Antioxidants (Basel, Switzerland), 10(7) (2021-08-07)
Parkinson's disease's etiology is unknown, although evidence suggests the involvement of oxidative modifications of intracellular components in disease pathobiology. Despite the known involvement of the extracellular matrix in physiology and disease, the influence of oxidative stress on the matrix has
C C Real et al.
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Physical exercise is known to produce beneficial effects to the nervous system. In most cases, brain-derived neurotrophic factor (BDNF) is involved in such effects. However, little is known on the role of BDNF in exercise-related effects on Parkinson's disease (PD).

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