H128
(R)(−)-α-甲基组胺 二盐酸盐
≥98% (HPLC), Histamine receptor agonist, solid
别名:
(R)(−)-α-Methyl-1H-imidazole-4-ethanamine dihydrochloride
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C6H11N3 · 2HCl
化学文摘社编号:
分子量:
198.09
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
(R)(−)-α-甲基组胺 二盐酸盐, solid, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D −4°, c = 0.8 in H2O(lit.)
storage condition
desiccated
color
white to off-white
solubility
H2O: soluble
SMILES string
Cl.Cl.C[C@@H](N)Cc1c[nH]cn1
InChI
1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1
InChI key
IZHCNQFUWDFPCW-ZJIMSODOSA-N
Gene Information
human ... HRH3(11255)
Application
(R)(−)-α-Methylhistamine dihydrochloride has been used as an agonist for the histamine H3 cell lines. It has also been used in the antagonist assay for the histamine H3 cell lines.
Biochem/physiol Actions
(R)(−)-α-Methylhistamine dihydrochloride is a potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier. It can inhibit histamine synthesis and release.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Magdalena Kotańska et al.
Biochemical pharmacology, 168, 193-203 (2019-07-12)
Histamine H3 receptors ligands act anorectic by blocking the H3 autoreceptors in the CNS, that results in increased synthesis and disinhibition of histamine release. Histamine further influencing H1 receptors participates in the leptin-dependent inhibition of food intake. It also affects
Structure-activity relations of histamine analogs. XX. Absolute configuration and histamine-like activity of enantiomeric α-methyl histamines.
Gerhard, et al.
Archives of Pharmacal Research, 313, 709-709 (1980)
J M Arrang et al.
Nature, 327(6118), 117-123 (1987-05-14)
New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provide new
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H128-5MG | 04061833664896 |
| H128-25MG | 04061833664858 |
| H128-100MG | 04061832091129 |