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Merck
CN

H1753

Sigma-Aldrich

肼屈嗪 盐酸盐

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

别名:

1-肼基二氮杂萘 盐酸盐

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关于此项目

经验公式（希尔记法）:
C8H8N4 · HCl
CAS Number:
304-20-1
分子量:
196.64
EC 号:
206-151-0
MDL编号:
MFCD00135998
UNSPSC代码:
12352200
PubChem化学物质编号:
24278461
NACRES:
NA.77

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Product Name

肼屈嗪 盐酸盐,

生物来源

synthetic (organic)

质量水平

100

方案

≥99% (TLC)

表单

powder

mp

273 °C

溶解性

water: 50 mg/mL

SMILES字符串

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

InChI key

SECXUXOCDLQOBI-MKFZHGHUSA-N

基因信息

human ... MAOA(4128), MAOB(4129)

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相关类别

应用

盐酸肼屈嗪已用于：
  • 研究其作为血管扩张药，对大鼠幼鼠T细胞频率升高相关高血压的影响
  • 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂，对心肌缺血再灌注(I/R)损伤的影响
  • 研究其作为血管扩张药，对胰岛素分泌和葡萄糖耐受的影响

生化/生理作用

抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂；降压药；氨基脲敏感性胺氧化酶抑制剂。
盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。

特点和优势

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ0814
MKCT3552
MKCQ8899
MKCR9220
MKCQ2237

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Scientific reports, 12(1), 11838-11838 (2022-07-14)
While clinical observations have confirmed a link between the development of neurodegenerative diseases and traumatic brain injuries (TBI), there are currently no treatments available and the underlying mechanisms remain elusive. In response, we have developed an in vitro pendulum trauma
Nadine S Sauter et al.
Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
Ruijia Feng et al.
Gut microbes, 16(1), 2390164-2390164 (2024-08-18)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model
Mahesh P Kate et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(1), 81-86 (2013-09-21)
Blood pressure (BP) reduction after intracerebral hemorrhage (ICH) is controversial, because of concerns that this may cause critical reductions in perihematoma perfusion and thereby precipitate tissue damage. We tested the hypothesis that BP reduction reduces perihematoma tissue oxygenation.Acute ICH patients
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