H1792
贯叶金丝桃素 二环己基铵盐
≥98% (HPLC), monoamine reuptake inhibitor, powder
别名:
Hyp-DCHA, 贯叶金丝桃素-DCHA
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关于此项目
经验公式（希尔记法）:
C35H52O4·C12H23N
化学文摘社编号:
分子量:
718.10
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
MDL number:
产品名称
贯叶金丝桃素 二环己基铵盐,
assay
≥98% (HPLC)
Quality Level
form
powder
storage condition
protect from light
color
white to off-white
solubility
DMSO: ≥10 mg/mL
storage temp.
−20°C
SMILES string
C1CCC(CC1)NC2CCCCC2.CC(C)C(=O)[C@@]34C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(\C)C)(C[C@H](C\C=C(/C)C)[C@@]3(C)CC\C=C(\C)C)C4=O
InChI
1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-;/m0./s1
InChI key
ZUYCAROZOLUHJY-DNSWOBEMSA-N
Biochem/physiol Actions
贯叶金丝桃素的稳定盐。
贯叶金丝桃素的稳定盐。贯叶金丝桃素被认为是负责圣约翰草′提取物的抗抑郁和抗焦虑特性的主要活性成分。它通过激活瞬时受体电位离子通道TRPC6充当单胺（包括5-羟色胺，去甲肾上腺素，多巴胺以及GABA和谷氨酸）的再摄取抑制剂。激活TRPC6可诱导钠和钙进入细胞，从而抑制单胺再摄取。它也是孕烷X受体（PXR）的激活剂，它是CYP3A4转录的关键调节剂，CYP3A4是细胞色素（CYP）P450酶系统的成员。最近的研究发现了其他神经系统作用，对炎症的作用以及抗菌、抗肿瘤和抗血管生成作用。
贯叶金丝桃素被认为是负责圣约翰草′提取物的抗抑郁和抗焦虑特性的主要活性成分。
贯叶金丝桃素被认为是负责圣约翰草′提取物的抗抑郁和抗焦虑特性的主要活性成分。它通过激活瞬时受体电位离子通道TRPC6充当单胺（包括5-羟色胺，去甲肾上腺素，多巴胺以及GABA和谷氨酸）的再摄取抑制剂。它也是孕烷X受体（PXR）的激活剂，它是CYP3A4转录的关键调节剂，CYP3A4是细胞色素（CYP）P450酶系统的成员。最近的研究发现它对阿尔茨海默氏′病（AD）神经病理学具有神经保护作用，包括在体外分解淀粉样蛋白β聚集体和改善体内空间记忆的能力。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jeong Hee Jeon et al.
Lung cancer (Amsterdam, Netherlands), 69(2), 165-171 (2009-12-01)
Lipid raft, a specialized membrane structure enriched with cholesterol and glycosphingolipid, contains molecules that convey environmental stimuli to the intracellular systems. Authors investigated the effects of raft cholesterol depletion on non-small cell lung cancer (NSCLC) cell migration. Incubation of NSCLC
Ying Zheng et al.
Cancer research, 69(3), 896-904 (2009-01-30)
Cyclooxygenase-2-derived prostaglandin E(2) (PGE(2)) stimulates tumor cell growth and progression. However, the mechanisms by which PGE(2) increases tumor growth remain incompletely understood. In studies performed in non-small cell lung carcinoma (NSCLC) cells, we found that PGE(2) stimulates the expression of
James A Lang et al.
The Journal of physiology, 588(Pt 8), 1361-1368 (2010-02-24)
The attenuated reflex vasoconstriction in aged skin may be partly mediated by oxidant-induced reduction in functional substrate and cofactor availability for noradrenaline biosynthesis. We hypothesized that localized supplementation of tyrosine and tetrahydrobiopterin (BH(4)) in aged human skin could augment reflex-
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H1792-1MG | 04061833700679 |