biological source
human
Quality Segment
recombinant
expressed in E. coli
form
liquid
concentration
1 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... H2BC1(255626)
General description
Histones are highly basic chromatin proteins. They tightly organize eukaryotic DNA into nucleosomes. A nucleosome exists as an octameric core histone comprising a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around the histone complex.
Biochem/physiol Actions
Histones are known to regulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. Extrachromosomal histone H2B functions as a cytosolic sensor and detects the double-stranded DNA (dsDNA) fragments produced from infectious agents or damaged cells. This stimulates innate and acquired immune responses in different cell types. Histone H2B moves in and out of the nucleosome more quickly than other core histones.
警示词
Danger
危险代码
预防性声明
Hazard Classifications
Carc. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable