H2380
6-羟基-DL-多巴
≥98% (HPLC), powder, APE1 inhibitor
别名:
2,4,5-三羟基-DL-苯丙氨酸, 2,5-二羟基-DL-酪氨酸
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关于此项目
经验公式（希尔记法）:
C9H11NO5
化学文摘社编号:
分子量:
213.19
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
2860065
产品名称
6-羟基-DL-多巴, ≥98% (HPLC), powder
InChI
1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
SMILES string
NC(Cc1cc(O)c(O)cc1O)C(O)=O
InChI key
YLKRUSPZOTYMAT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
H2O: 3 mg/mL
1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
6-羟基-DL-DOPA是APE1（紫杉醇/嘧啶内切核酸酶）修复功能活性的一种抑制剂。APE1是一种对DNA碱基切除修复途径至关重要的核酸酶。6-羟基-DL-DOPA还可封闭RAD52（DNA修复蛋白）单链DNA结合结构域。
6-羟基多巴胺前体。
儿茶酚胺能神经毒素6-羟基多巴胺的前体；通过L-芳族氨基酸脱羧酶转化为6-羟基多巴胺。
Disclaimer
吸湿；光敏感
General description
溶于含有0.1％偏亚硫酸氢钠或其他抗氧化剂的煮沸过的无氧水中。溶液应新鲜制备，并且应避光。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Gurushankar Chandramouly et al.
Chemistry & biology, 22(11), 1491-1504 (2015-11-10)
Suppression of RAD52 causes synthetic lethality in BRCA-deficient cells. Yet pharmacological inhibition of RAD52, which binds single-strand DNA (ssDNA) and lacks enzymatic activity, has not been demonstrated. Here, we identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor
Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase.
G W Adams et al.
Methods in enzymology, 258, 90-114 (1995-01-01)
F Karoum et al.
Journal of neurochemistry, 61(4), 1369-1375 (1993-10-01)
Formation of 6-hydroxydopamine (6-OHDA) from dopamine has been hypothesized to mediate neurodegeneration induced by some psychostimulants. Although the emergence of a 6-OHDA-like substance was reported in the striatum of methamphetamine-treated rats, this substance has not been identified by a direct
E K Y Chung et al.
Neuro-Signals, 15(5), 238-248 (2007-04-17)
Overactivity of the glutamatergic system is suggested to be closely related to the onset and pathogenesis of Parkinson's disease. Vesicular glutamate transporters (VGLUT1, T2 and T3) are a group of glutamate transporters in neurons that are responsible for transporting glutamate
Adnan Azeem et al.
International journal of pharmaceutics, 422(1-2), 436-444 (2011-11-08)
Ropinirole, a recent introduction in the clinical treatment of Parkinson's disease, suffers with the problems of low oral bioavailability and frequent dosing. An effective transdermal nano-emulsion drug delivery system can however resolve these issues effectively with greater therapeutic benefits and
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