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H2380

6-羟基-DL-多巴

Name: 6-羟基-<SC>DL</SC>-多巴
Brand: SIGMA

≥98% (HPLC), powder, APE1 inhibitor

别名:

2,4,5-三羟基-DL-苯丙氨酸, 2,5-二羟基-DL-酪氨酸

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关于此项目

经验公式（希尔记法）:

C₉H₁₁NO₅

化学文摘社编号:

21373-30-8

分子量:

213.19

NACRES:

NA.32

PubChem Substance ID:

24278464

UNSPSC Code:

12352200

MDL number:

MFCD00004272

Beilstein/REAXYS Number:

2860065

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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产品名称

6-羟基-DL-多巴, ≥98% (HPLC), powder

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H₂O: 3 mg/mL, 1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)

storage temp.

−20°C

SMILES string

NC(Cc1cc(O)c(O)cc1O)C(O)=O

InChI

1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)

InChI key

YLKRUSPZOTYMAT-UHFFFAOYSA-N

General description

溶于含有0.1％偏亚硫酸氢钠或其他抗氧化剂的煮沸过的无氧水中。溶液应新鲜制备，并且应避光。

Biochem/physiol Actions

6-羟基-DL-DOPA是APE1（紫杉醇/嘧啶内切核酸酶）修复功能活性的一种抑制剂。APE1是一种对DNA碱基切除修复途径至关重要的核酸酶。6-羟基-DL-DOPA还可封闭RAD52（DNA修复蛋白）单链DNA结合结构域。

6-羟基多巴胺前体。

儿茶酚胺能神经毒素6-羟基多巴胺的前体；通过L-芳族氨基酸脱羧酶转化为6-羟基多巴胺。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

Disclaimer

吸湿；光敏感

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Suppression of RAD52 causes synthetic lethality in BRCA-deficient cells. Yet pharmacological inhibition of RAD52, which binds single-strand DNA (ssDNA) and lacks enzymatic activity, has not been demonstrated. Here, we identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor

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G W Adams et al.

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Oil based nanocarrier system for transdermal delivery of ropinirole: a mechanistic, pharmacokinetic and biochemical investigation.

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A J Nappi et al.

Biochimica et biophysica acta, 1201(3), 498-504 (1994-12-15)

The interactions of ascorbic acid (AA) and reduced glutathione (GSH) in the oxidations of the catecholaminergic neurotoxins 6-hydroxydopa (TOPA) and 6-hydroxydopamine (6-OHDA) were investigated by both high performance liquid chromatography with electrochemical detection (HPLC-ED) and spectrometric methods. These comparative studies

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Although several nucleo(s)tide analogs are available for treatment of HBV infection, long-term treatment with these drugs can lead to the emergence of drug-resistant viruses. Recent HIV-1 studies suggest that combination therapies using nucleo(s)tide reverse transcriptase inhibitors (NRTIs) and non-nucleo(s)tide reverse

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全球贸易项目编号

货号	GTIN
H2380-100MG	04061833007365
H2380-10MG	04061833007372
H2380-5MG	04061833007389

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