H2414
抗-Humanin（HN） 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
人源化蛋白检测抗体, 兔抗人源化蛋白
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: 1:500
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MT-RNR2(4550)
General description
Humanin（HN）是一种小的多肽，来源于线粒体。这种蛋白质由各种细胞分泌，位于血浆中并与细胞膜结合。
Immunogen
一种与人蛋白（氨基酸9-24）相对应的肽。
Application
兔生产的抗 Humanin（HN）抗体已被用于：
- 免疫组化
- 免疫沉淀(1:300)
- 免疫荧光(1:300)
- 免疫印迹(1:500)
Biochem/physiol Actions
Humanin（HN）是一种神经保护因子。它参与促进细胞存活。Humanin 抑制由阿尔茨海默′病相关损伤引起的神经元细胞死亡，这些相关损伤如抗淀粉样蛋白前体蛋白抗体、神经毒性淀粉样蛋白 β (Aβ) 肽和家族性阿尔茨海默病蛋白。
Physical form
溶剂为含有0.02％叠氮化钠的1 mg/mL磷酸盐缓冲生理盐水。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Jon-Philippe K Hyatt et al.
Journal of dietary supplements, 20(4), 563-581 (2022-03-02)
Mitochondrial biogenesis and destruction in skeletal muscle are coordinated by distinct signaling pathways that are influenced by internal and exogenous variables including, but not limited to, muscle phenotype, physical activity, dietary composition, or drug administration. Previously we found that long-term
Yue Jia et al.
Biology of reproduction, 104(3), 717-730 (2020-12-18)
Humanin (HN) is a mitochondrial-derived peptide that protects many cells/tissues from damage. We previously demonstrated that HN reduces stress-induced male germ cell apoptosis in rodents. HN action in neuronal cells is mediated through its binding to a trimeric cell membrane
Mariela A Moreno Ayala et al.
Scientific reports, 10(1), 8542-8542 (2020-05-24)
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor
Radhika H Muzumdar et al.
PloS one, 4(7), e6334-e6334 (2009-07-23)
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against
Jon-Philippe K Hyatt
Physiological reports, 10(13), e15377-e15377 (2022-07-10)
Skeletal muscle adapts to aerobic exercise training, in part, through fast-to-slow phenotypic shifts and an expansion of mitochondrial networks. Recent research suggests that the local and systemic benefits of exercise training also may be modulated by the mitochondrial-derived peptide, MOTS-c.
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