H2915
HCK (230-497), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
JTK9
产品名称
HCK (230-497), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
recombinant
expressed in baculovirus infected Sf9 cells
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
156-212 nmol/min·mg
mol wt
~57 kDa
UniProt accession no.
relevant disease(s)
cancer (leukemia)
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... HCK(3055)
Biochem/physiol Actions
HCK (hematopoietic cell kinase) gene is mapped to human chromosome 20q11-q12. This region on the chromosome urdergoes interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders, thereby suggesting HCK participation in the pathogenesis of these conditions.
General description
HCK (hematopoietic cell kinase), a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells. It is especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
S F Ziegler et al.
Molecular and cellular biology, 7(6), 2276-2285 (1987-06-01)
Protein-tyrosine kinases are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes and as components of growth factor receptors. Here we report the characterization of a novel human protein-tyrosine kinase gene
N Quintrell et al.
Molecular and cellular biology, 7(6), 2267-2275 (1987-06-01)
We have isolated cDNAs representing a previously unrecognized human gene that apparently encodes a protein-tyrosine kinase. We have designated the gene as HCK (hemopoietic cell kinase) because its expression is prominent in the lymphoid and myeloid lineages of hemopoiesis. Expression
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