H3167
盐酸羟基安非他酮
≥98% (HPLC), DAT and NET inhibitor, powder
别名:
盐酸安非他酮吗啉代杂质, GW 353162, SS-羟基安非他酮盐酸盐, 盐酸拉达法辛, （+）-（2S，3S）-2-（3-氯苯基）-3,5,5-三甲基-2-吗啉代盐酸盐, （2S，3S）-2-（3-氯苯基）-3,5,5-三甲基-2-吗啉代盐酸盐
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关于此项目
经验公式（希尔记法）:
C13H18ClNO2 · HCl
化学文摘社编号:
分子量:
292.20
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
盐酸羟基安非他酮, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥12 mg/mL
storage temp.
−20°C
SMILES string
Cl.C[C@@H]1NC(C)(C)CO[C@@]1(O)c2cccc(Cl)c2
InChI
1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1
InChI key
ORXTVTDGPVINDN-BTJVGWIPSA-N
General description
(2S,3S)-羟基安非他酮是安非他酮的主要代谢产物。
Biochem/physiol Actions
（2S，3S）-羟基安非他酮是多巴胺转运蛋白（DAT）和去甲肾上腺素转运蛋白（NET）转运蛋白抑制剂和烟碱型乙酰胆碱受体（nAChR）家族调节剂。 据报道，羟基安非他酮有助于抗抑郁和戒烟。(2S,3S)和(2R,3R)代谢产物均可逆转尼古丁依赖性小鼠的情感和躯体戒断症状，但(2S,3S)-羟基安非他酮更有效。(2S,3S)-羟基安非他酮可显著降低小鼠的尼古丁奖赏效应。
Features and Benefits
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Matthew L Banks et al.
Behavioural pharmacology, 27(2-3 Spec Issue), 196-203 (2016-02-18)
The dopamine transporter (DAT) inhibitor and nicotinic acetylcholine (nACh) receptor antagonist bupropion is being investigated as a candidate 'agonist' medication for methamphetamine addiction. In addition to its complex pharmacology, bupropion also has two distinct pharmacologically active metabolites. However, the mechanism
E Malcolm et al.
Psychopharmacology, 232(15), 2763-2771 (2015-03-13)
Preclinical studies with bupropion in rodent models of nicotine dependence have generated equivocal findings with regard to translating the clinical efficacy of the antidepressant as a smoking cessation agent. Given that rats are poor metabolizers of bupropion, the present experiments
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H3167-5MG | 04061832082448 |
| H3167-25MG | 04061832082431 |