Merck
CN

H3884

Sigma-Aldrich

透明质酸酶 来源于牛睾丸

Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

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别名:
玻璃糖醛酸酶, 玻璃酸酶
CAS号:
EC 号:
MDL编号:

生物来源

bovine testis

质量水平

偶联物

conjugate (Glucosaminoglycan)

类型

Type IV-S

形式

lyophilized powder (essentially salt-free)

specific activity

750-3000 units/mg solid

分子量

~55 kDa (four subunits of 14 kDa each)

UniProt登记号

application(s)

diagnostic assay manufacturing

相关疾病

cancer

储存温度

−20°C

Gene Information

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此商品
H3757V900833H3631
form

lyophilized powder (essentially salt-free)

form

lyophilized powder

form

powder

form

lyophilized powder

specific activity

750-3000 units/mg solid

specific activity

300-1,000 U/mg

specific activity

≥750 units/mg solid

specific activity

3,000-15,000 units/mg solid

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

-

mol wt

~55 kDa (four subunits of 14 kDa each)

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

-

UniProt accession no.

Q5E985, Q8SQG8

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

-

application(s)

-

生化/生理作用

这些酶可随机裂解透明质酸、软骨素和硫酸软骨素中的 β-N-乙酰己糖胺-[1→4] 糖苷键。
透明质酸酶可降解透明质酸,并已发现可在癌症进展期间会被不适当地调节。

单位定义

在 37 ºC、pH 5.35 条件下,一单位每分钟可降解 0.75 μg 多糖透明质酸(通过比浊吸光度测量(λ: 600nm),与 BSA 复合 45 分钟后测量)。

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Resp. Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. Can stock solutions of Product H3884, Hyaluronidase from bovine testes, be stored frozen after reconstitution?

    Although Sigma-Aldrich has not tested the stability of stock solutions of Product H3884, Hyaluronidase from bovine testes, several publications cite storage of solutions of H3884 at -20 °C:1.  Campbell, Keith H.S, "Transgenic Sheep form Cultured Cells", from Transgenesis Techniques: Principles and Protocols, Methods Mol. Biol., 180, 289-301 (2002).  A 1500 IU/mL stock solution was stored in 20 mL aliquots at -20 °C.2.  Marschall, S. and de Angelis, M.H., "In Vitro Fertilization/Cryopreservation", from Transgenic Mouse: Methods and Protocols, Methods in Molecular Biology, 209, pp. 35-50. Humana Press (2003).  1 mg/mL stock solutions in M2 medium or water, sterile-filtered (0.22 mm filter) can be stored in aliquots at -20 °C.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Alicia Santos Savio et al.
BMC musculoskeletal disorders, 16, 51-51 (2015-04-17)
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Claire M McLeod et al.
Scientific reports, 6, 38852-38852 (2016-12-13)
Extracellular matrix dynamics are key to tissue morphogenesis, homeostasis, injury, and repair. The spatiotemporal organization of this matrix has profound biological implications, but is challenging to monitor using standard techniques. Here, we address these challenges by using noncanonical amino acid
Matthew R Kent et al.
Neural regeneration research, 16(2), 367-374 (2020-08-30)
A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that
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Reactive oxygen species (ROS) have been proposed as signaling molecules mediating exercise training adaptation, but the ROS source has remained unclear. This study aimed to investigate if increased NADPH oxidase (NOX)2-dependent activity during exercise is required for long-term high-intensity interval
Claire E McKellar et al.
eLife, 9 (2020-06-26)
We describe the anatomy of all the primary motor neurons in the fly proboscis and characterize their contributions to its diverse reaching movements. Pairing this behavior with the wealth of Drosophila's genetic tools offers the possibility to study motor control

商品

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

实验方案

Enzymatic Assay of Hyaluronidase (3.2.1.35)

This procedure may be used for Hyaluronidase products.

透明质酸酶的酶法测定 (3.2.1.35)

在测定透明质酸酶活性时,使用了一种在600 nm处的比浊测定法进行测定。在pH 5.35、37 °C下,一单位的透明质酸酶活性可每分钟引起0.330的吸光值改变。

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