H4002
DL-3-羟基降缬氨酸
≥98% (TLC)
别名:
HNV, α-氨基-β-羟基戊酸, 2-氨基-3-羟基戊酸, 3-羟基-2-氨基戊酸, DL-β-羟基降缬氨酸
产品名称
DL-3-羟基降缬氨酸, ≥98% (TLC)
质量水平
方案
≥98% (TLC)
表单
powder
颜色
white
应用
cell analysis
储存温度
−20°C
SMILES字符串
CCC(O)C(N)C(O)=O
InChI
1S/C5H11NO3/c1-2-3(7)4(6)5(8)9/h3-4,7H,2,6H2,1H3,(H,8,9)
InChI key
LGVJIYCMHMKTPB-UHFFFAOYSA-N
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生化/生理作用
3-羟基正缬氨酸（HNV）是一种微生物α氨基酸苏氨酸类似物，具有抗病毒活性（疱疹病毒）并可通过插入到蛋白中而对哺乳动物细胞产生毒性（胚胎毒性和致畸性）。3-羟基正缬氨酸可作为一种非天然氨基酸用于研究在酰基-tRNA编辑水平上蛋白翻译的保真度。3-羟基正缬氨酸也可用于研究苏氨酸代谢中所涉及的酶和分子。
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
R Louw et al.
Amino acids, 29(3), 207-212 (2005-08-06)
3-Hydroxynorvaline (HNV; 2-amino-3-hydroxypentanoic acid), a microbial L-threonine analogue, is toxic to mammalian cells and displays antiviral properties. In view of this, we investigated the toxicity and/or potential teratogenicity of HNV in developing chicken and mouse embryos. HNV was administered to
C Ramos et al.
Applied and environmental microbiology, 58(5), 1677-1682 (1992-05-01)
In this work, we isolated and characterized mutants that overproduce threonine from Saccharomyces cerevisiae. The mutants were selected for resistance to the threonine analog alpha-amino-beta-hydroxynorvalerate (hydroxynorvaline), and, of these, the ones able to excrete threonine to the medium were chosen.
R Kumarasamy et al.
Virology, 138(1), 156-161 (1984-10-15)
Treatment of HSV-infected BHK-21 cells with 5-10 mM of beta-hydroxynorvaline (Hnv), an analog of threonine which blocked attachment of oligosaccharides at the Asn-X-Thr sites, markedly inhibited the synthesis of all viral glycoproteins as well as the major capsid protein. However
E G Green et al.
The Journal of steroid biochemistry and molecular biology, 40(1-3), 421-429 (1991-01-01)
We have investigated the ability of amino acid analogues of serine and threonine to inhibit the increase in steroidogenesis elicited by addition of ACTH or cAMP in cells isolated from the rat adrenal cortex. We have found that the serine
P A Docherty et al.
The Journal of biological chemistry, 260(19), 10847-10855 (1985-09-05)
The threonine analog beta-hydroxynorvaline (Hnv) is an inhibitor of asparagine-linked glycosylation. In the presence of the analog hepatocytes synthesized immunoreactive alpha 1-acid glycoprotein with 0-6 oligosaccharide chains. Pulse-chase experiments were conducted to compare the rates of secretion of alpha 1-acid
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