H4002
DL-3-羟基降缬氨酸
≥98% (TLC)
别名:
HNV, α-氨基-β-羟基戊酸, 2-氨基-3-羟基戊酸, 3-羟基-2-氨基戊酸, DL-β-羟基降缬氨酸
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关于此项目
经验公式（希尔记法）:
C5H11NO3
化学文摘社编号:
分子量:
133.15
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Beilstein/REAXYS Number:
1722350
MDL number:
产品名称
DL-3-羟基降缬氨酸, ≥98% (TLC)
SMILES string
CCC(O)C(N)C(O)=O
InChI key
LGVJIYCMHMKTPB-UHFFFAOYSA-N
InChI
1S/C5H11NO3/c1-2-3(7)4(6)5(8)9/h3-4,7H,2,6H2,1H3,(H,8,9)
assay
≥98% (TLC)
form
powder
color
white
application(s)
cell analysis
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
3-羟基正缬氨酸（HNV）是一种微生物α氨基酸苏氨酸类似物，具有抗病毒活性（疱疹病毒）并可通过插入到蛋白中而对哺乳动物细胞产生毒性（胚胎毒性和致畸性）。3-羟基正缬氨酸可作为一种非天然氨基酸用于研究在酰基-tRNA编辑水平上蛋白翻译的保真度。3-羟基正缬氨酸也可用于研究苏氨酸代谢中所涉及的酶和分子。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Y J Gordon et al.
Current eye research, 5(2), 93-99 (1986-02-01)
The present study examined the anti-herpetic effect of the glycoprotein inhibitors, hydroxynorvaline and 2-deoxyglucose, alone and in combination with trifluridine on murine ocular herpes. Following ocular inoculation with a large dose of HSV-1 RE strain (10(6) pfu), ICR mice were
F A Barile et al.
Archives of biochemistry and biophysics, 270(1), 294-301 (1989-04-01)
Amino acid substitutions in collagen that impair folding of the triple helix result in significant increases in intracellular degradation of newly synthesized collagen. We have studied the effects of agents that cause other kinds of defects in collagen: hydroxynorvaline, a
G Hortin et al.
The Journal of biological chemistry, 255(15), 7051-7054 (1980-08-10)
The proteolytic processing of rat pre-prolactin (Pre-Prl) to prolactin in isolated hemipituitaries was inhibited by the threonine analog, beta-hydroxynorvaline (Hnv). Pre-Prl accumulated as a major labeled intracellular product, even during pulse labeling longer than 2 h, but it was not
C Ramos et al.
Applied and environmental microbiology, 58(5), 1677-1682 (1992-05-01)
In this work, we isolated and characterized mutants that overproduce threonine from Saccharomyces cerevisiae. The mutants were selected for resistance to the threonine analog alpha-amino-beta-hydroxynorvalerate (hydroxynorvaline), and, of these, the ones able to excrete threonine to the medium were chosen.
R Louw et al.
Amino acids, 29(3), 207-212 (2005-08-06)
3-Hydroxynorvaline (HNV; 2-amino-3-hydroxypentanoic acid), a microbial L-threonine analogue, is toxic to mammalian cells and displays antiviral properties. In view of this, we investigated the toxicity and/or potential teratogenicity of HNV in developing chicken and mouse embryos. HNV was administered to
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