H4014
25-羟基胆钙化醇
≥98% (HPLC)
别名:
25-羟基维生素D3
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关于此项目
经验公式（希尔记法）:
C27H44O2
CAS Number:
分子量:
400.64
EC 号:
MDL编号:
UNSPSC代码:
12352205
PubChem化学物质编号:
NACRES:
NA.79
质量水平
方案
≥98% (HPLC)
表单
powder
技术
HPLC: suitable
颜色
white to off-white
储存温度
−20°C
SMILES字符串
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C
InChI
1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
InChI key
JWUBBDSIWDLEOM-DTOXIADCSA-N
基因信息
human ... VDR(7421)
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应用
- 25-羟胆钙化醇的免疫测定开发：对动物饲料用酿酒酵母产生的25-羟胆钙化醇的安全性和有效性调查强调了其在开发监测动物体内维生素D水平的免疫测定中的潜在应用，为人类诊断中的类似应用奠定了基础（欧洲食品安全局添加剂和产品小组，2023 年）。
生化/生理作用
麦角钙化醇（维生素D2）和25-羟基胆钙化醇（维生素D3）是维生素D的两种形式，它们可通过羟基化在 体内 活化。 维生素D2和D3可用于广泛的研究，以评估其对免疫功能和钙稳态等功能的影响。
警示用语：
Danger
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Abboud et al.
Endocrinology, 154(9), 3022-3030 (2013-07-05)
Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In
Richard McKenzie et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 12(9), 1726-1737 (2013-06-29)
To clarify the relation between UV exposure and vitamin D status, 201 volunteers wore personal electronic UV dosimeters during daylight hours, to record their UV exposure over a 10 week period when ambient UV levels were significantly less than the
Jerry Liu et al.
Food chemistry, 140(3), 432-435 (2013-04-23)
There is little information on the vitamin D content of Australian red meat or on the possible influence of latitude on this content. To determine the content of vitamin D3 and 25-hydroxy-vitamin D3 (25OHD3), lamb and beef were analysed from
Julia Höbaus et al.
International journal of cancer, 133(6), 1380-1388 (2013-03-07)
In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). However, the underlying mechanism of CYP24A1 overexpression is poorly understood. In
Bianca Weinstock-Guttman et al.
Journal of neurology, neurosurgery, and psychiatry, 84(11), 1186-1191 (2013-04-19)
To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment
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