H4413
羟基法舒 盐酸盐 水合物
≥98% (HPLC), solid
别名:
1-（1-羟基-5-异喹啉磺酰）高哌嗪 盐酸盐 水合物
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关于此项目
经验公式（希尔记法）:
C14H17N3O3S · HCl · xH2O
化学文摘社编号:
分子量:
343.83 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
XWWFOUVDVJGNNG-UHFFFAOYSA-N
SMILES string
Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
assay
≥98% (HPLC)
form
solid
composition
The two peaks show the equilibrim between the two tautomers
color
white
solubility
H2O: >5 mg/mL
storage temp.
2-8°C
Quality Level
Application
羟基法舒地尔盐酸盐水合物已被用作ROCK抑制剂，用于研究化学增活素 CCL19 和CCL21中不同信号传导通路的作用，CLL 细胞中CCR7 配体介导的迁移和促存活作用。
Biochem/physiol Actions
Rho 激酶抑制剂。
羟基法舒地尔具有抗痉挛作用。它是法舒地尔的活性代谢产物。羟基法舒地尔可能增强血流动力学并防止中性粒细胞导致的损伤。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage
Satoh SI, et al.
Life Sciences, 69(12), 1441-1453 (2001)
Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia
Cuesta-Mateos C, et al.
Experimental Hematology, 38(9), 756-764 (2010)
Ghulam Mohammad et al.
Annals of clinical and laboratory science, 48(2), 137-145 (2018-04-22)
To investigate the effects of blocking Rho kinase pathway on the expression of inflammatory signaling pathways in the retina of diabetic mice and in human retinal Müller glial cells stimulated with high-glucose to replicate hyperglycemia. Retinas from diabetic mice and
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