H4415
HC-030031
≥98% (HPLC), TRPA1 channel blocker, powder
别名:
1,2,3,6-四氢-1,3-二甲基-N- [4-（1-甲基乙基）苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺, 2-（1,3-二甲基-2,6-二氧代-1,2,3,6-四氢-7H-嘌呤-7-基）-N-（4-异丙基苯基）乙酰胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H21N5O3
化学文摘社编号:
分子量:
355.39
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.25
MDL number:
产品名称
HC-030031, ≥98% (HPLC), powder
SMILES string
CC(C)c1ccc(NC(=O)Cn2cnc3N(C)C(=O)N(C)C(=O)c23)cc1
InChI key
HEQDZPHDVAOBLN-UHFFFAOYSA-N
InChI
1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
Quality Level
相关类别
Biochem/physiol Actions
HC-030031是一种选择性TRPA1通道阻滞剂。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流。IC50为5 μM。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流以及福尔马林诱导的疼痛。IC50为5 μM。TRPA1拮抗作用是慢性炎症或神经源性疼痛的一种潜在治疗靶标。
存储类别
11 - Combustible Solids
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
wgk
WGK 2
flash_point_f
No data available
flash_point_c
No data available
Luana Fischer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 311-322 (2016-12-03)
Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo. In this study we evaluated whether TRPA1, SP, histamine and 5-HT
Éva Borbély et al.
Frontiers in pharmacology, 11, 594479-594479 (2021-02-02)
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. Therefore, we
Coline Legrand et al.
Scientific reports, 10(1), 11238-11238 (2020-07-10)
The transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction
Florian Schillers et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 18-25 (2016-07-28)
Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery. PPCM is rapidly hydrolyzed by plasma esterases to PCM and diethylglycine and shares some structural and metabolic properties with lidocaine.
Anthony Bosson et al.
Molecular neurodegeneration, 12(1), 53-53 (2017-07-08)
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes
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