H4415
HC-030031
≥98% (HPLC), TRPA1 channel blocker, powder
别名:
1,2,3,6-四氢-1,3-二甲基-N- [4-（1-甲基乙基）苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺, 2-（1,3-二甲基-2,6-二氧代-1,2,3,6-四氢-7H-嘌呤-7-基）-N-（4-异丙基苯基）乙酰胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H21N5O3
化学文摘社编号:
分子量:
355.39
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.25
产品名称
HC-030031, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
room temp
SMILES字符串
CC(C)c1ccc(NC(=O)Cn2cnc3N(C)C(=O)N(C)C(=O)c23)cc1
InChI
1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
InChI key
HEQDZPHDVAOBLN-UHFFFAOYSA-N
生化/生理作用
HC-030031是一种选择性TRPA1通道阻滞剂。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流。IC50为5 μM。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流以及福尔马林诱导的疼痛。IC50为5 μM。TRPA1拮抗作用是慢性炎症或神经源性疼痛的一种潜在治疗靶标。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Coline Legrand et al.
Scientific reports, 10(1), 11238-11238 (2020-07-10)
The transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction
Luana Fischer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 311-322 (2016-12-03)
Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo. In this study we evaluated whether TRPA1, SP, histamine and 5-HT
Éva Borbély et al.
Frontiers in pharmacology, 11, 594479-594479 (2021-02-02)
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. Therefore, we
Yan Xu et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 29(6), 692-700 (2018-11-02)
Transient receptor potential ankyrin 1 (TRPA1) and substance P (SP), both expression in sensory neurons, have important roles in stress-induced duodenal lesions. The possible contribution of TRPA1 and SP to stress-induced duodenal lesions was explored by using the water immersion
Florian Schillers et al.
The Journal of pharmacology and experimental therapeutics, 359(1), 18-25 (2016-07-28)
Propacetamol (PPCM) is a prodrug of paracetamol (PCM), which was generated to increase water solubility of PCM for intravenous delivery. PPCM is rapidly hydrolyzed by plasma esterases to PCM and diethylglycine and shares some structural and metabolic properties with lidocaine.
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