H4415
HC-030031
≥98% (HPLC), TRPA1 channel blocker, powder
别名:
1,2,3,6-四氢-1,3-二甲基-N- [4-（1-甲基乙基）苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺, 2-（1,3-二甲基-2,6-二氧代-1,2,3,6-四氢-7H-嘌呤-7-基）-N-（4-异丙基苯基）乙酰胺
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H21N5O3
化学文摘社编号:
分子量:
355.39
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.25
产品名称
HC-030031, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
room temp
SMILES字符串
CC(C)c1ccc(NC(=O)Cn2cnc3N(C)C(=O)N(C)C(=O)c23)cc1
InChI
1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
InChI key
HEQDZPHDVAOBLN-UHFFFAOYSA-N
相关类别
生化/生理作用
HC-030031是一种选择性TRPA1通道阻滞剂。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流。IC50为5 μM。
HC-030031是一种选择性TRPA1通道阻滞剂。HC-030031可拮抗福尔马林诱发的钙内流以及福尔马林诱导的疼痛。IC50为5 μM。TRPA1拮抗作用是慢性炎症或神经源性疼痛的一种潜在治疗靶标。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Coline Legrand et al.
Scientific reports, 10(1), 11238-11238 (2020-07-10)
The transient receptor potential (TRP) channels family are cationic channels involved in various physiological processes as pain, inflammation, metabolism, swallowing function, gut motility, thermoregulation or adipogenesis. In the oral cavity, TRP channels are involved in chemesthesis, the sensory chemical transduction
Luana Fischer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 311-322 (2016-12-03)
Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo. In this study we evaluated whether TRPA1, SP, histamine and 5-HT
Yan Xu et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 29(6), 692-700 (2018-11-02)
Transient receptor potential ankyrin 1 (TRPA1) and substance P (SP), both expression in sensory neurons, have important roles in stress-induced duodenal lesions. The possible contribution of TRPA1 and SP to stress-induced duodenal lesions was explored by using the water immersion
Cristina Moldovan Loomis et al.
The Journal of pharmacology and experimental therapeutics, 369(1), 26-36 (2019-01-16)
Migraine is a debilitating disease that affects almost 15% of the population worldwide and is the first cause of disability in people under 50 years of age, yet its etiology and pathophysiology remain incompletely understood. Recently, small molecules and therapeutic
Yu-Wei Wu et al.
Glia, 67(2), 246-262 (2018-12-20)
Astrocytes express a complex repertoire of intracellular Ca2+ transients (events) that represent a major form of signaling within individual cells and in astrocytic syncytium. These events have different spatiotemporal profiles, which are modulated by neuronal activity. Spontaneous Ca2+ events appear
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