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H4637

4-羟基雌二醇

Name: 4-羟基雌二醇
Brand: SIGMA

别名:

1,3,5(10)-Estratriene-3,4,17β-triol

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₄O₃

化学文摘社编号:

5976-61-4

分子量:

288.38

NACRES:

NA.77

PubChem Substance ID:

24895648

UNSPSC Code:

51111800

MDL number:

MFCD00063335

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属性

storage temp.

−20°C

Quality Level

100

SMILES string

[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4c(O)c(O)ccc24

InChI

1S/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11-,12-,14+,16+,18+/m1/s1

InChI key

QOZFCKXEVSGWGS-ZHIYBZGJSA-N

Gene Information

human ... ESR1(2099)
rat ... Ar(24208)

说明

Biochem/physiol Actions

4-Hydroxyestradiol, an metabolite of estradiol, forms adducts with adenine (N³) and guanine (N⁷) by depurinating sites in DNA of cultured human breast epithelial cells. This effect may play an important role in malignant transformation of these cells.

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pictograms

GHS08

signalword

Warning

hcodes

H351

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects.

Richard Santen et al.

Annals of the New York Academy of Sciences, 1155, 132-140 (2009-03-03)

Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol

ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.

Susana Lin et al.

Lung cancer (Amsterdam, Netherlands), 75(3), 285-292 (2011-09-17)

Women have a higher risk of lung adenocarcinoma than men, suggesting that estrogen pathway may be involved in the pathogenesis of this cancer. This study was designed to determine whether ERα expression, estrogen levels, and endocrine disruptor exposure would influence

4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species.

Sin-Aye Park et al.

Cancer research, 69(6), 2416-2424 (2009-03-12)

Estrogen is converted by cytochrome P450 1B1 to 4-hydroxyestradiol (4-OHE(2)), a putative carcinogenic metabolite of estrogen. This catechol estrogen metabolite is oxidized further to produce a reactive quinone via semiquinone. Redox cycling between 4-OHE(2) and its quinoid generates reactive oxygen

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全球贸易项目编号

货号	GTIN
H4637-5MG	04061833271483
H4637-1MG	04061833795767