H4652
HMG-1 Peptide
≥90% (SDS-PAGE), lyophilized powder, Histidine-tagged, human recombinant, expressed in E. coli
别名:
HMGB1, 两性霉素, 高迁移率族蛋白
产品名称
HMG-1 人, lyophilized powder, ≥90% (SDS-PAGE), Histidine-tagged, recombinant, expressed in E. coli
InChI key
WQCYAHKAJFZVCO-UHFFFAOYSA-N
SMILES string
COC(=O)CCCCCCCCCCCCCCO
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
25 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... HMGB1(3146)
Analysis Note
DNA 延迟测定试验
Application
HMG-1（高迁移率族蛋白）人已用于：
- 使用ELISA（酶联免疫吸附测定）测试，制备用于测量 HMG1的标准曲线
- 研究在外源 HMG-1 存在下 Lewis细胞的凋亡比例
- 研究在体外条件下，HMG-1 存在时，Th（T辅助细胞）-17细胞扩增的变化
- 用于GM7373细胞的迁移测定
Biochem/physiol Actions
HMG-1（高迁移率族蛋白）是非组蛋白染色体蛋白，其促进蛋白质序列特异性 DNA 附着。HMG1以非序列特异性方式结合 DNA。它参与DNA 复制、转录和修复。此外，它在癌症中上调并且与细胞生长、血管发生和细胞凋亡调节有关。在感染或损伤的情况下，HMG1 被分泌并介导炎症。它与自身免疫疾疾病的发病机制有关，例如类风湿性关节炎（RA）、炎性肠病（IBD）和系统性红斑狼疮（SLE）。
General description
215个氨基酸。由两个同源HMG盒组成，富含碱性氨基酸，羧基端带酸性尾
HMG-1（高迁移率族蛋白）是分子量为30kDa的核蛋白。它由巨噬细胞、单核细胞和坏死细胞分泌。它广泛表达。该蛋白质具有碱性 HMG（高迁移率族）盒结构域和酸性羧基末端。
Physical form
含有HEPES 缓冲盐，pH 7.8，NaCl，EDTA，Triton X-100，亮抑酶肽和AEBSF的冻干粉。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
常规特殊物品
此项目有
Tian-Tian Ma et al.
PloS one, 10(4), e0123586-e0123586 (2015-04-18)
High mobility group box-1 (HMGB1), a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In
X Xu et al.
Scandinavian journal of immunology, 79(6), 386-394 (2014-03-29)
Upregulated high-mobility group box 1 (HMGB1) has been found in many diseases. Nevertheless, the function of HMGB1 on modulating the proliferation of lung cancer cells (Lewis cells) and inhibiting apoptosis is poorly understood, as well as the involved intracellular signalling.
A Taguchi et al.
Nature, 405(6784), 354-360 (2000-06-01)
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. Engagement of
Jinfeng Li et al.
Pharmaceutical biology, 54(12), 3217-3225 (2016-08-27)
High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory. Some experiments have demonstrated a vital role for HMGB1 to modulate the immune function of regulatory T-cells (Tregs). Astragaloside IV (AST IV)
Quang D Trinh et al.
Clinical laboratory, 62(12), 2305-2311 (2017-02-07)
High-mobility group box 1 (HMGB1), a DNA-binding protein, has recently been shown to have effects on HIV replication, but the effects are dependent on the cell type and the timing of infection. Using human primary T cells, this study aimed
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