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Merck
CN

H4881

氢化可的松琥珀酸酯 钠盐

synthetic (organic), ≥90% (HPLC), Glucocorticoid receptor agonist, powder

别名:

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate 钠盐, 氢化可的松 21-半琥珀酸酯 钠盐

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关于此项目

经验公式（希尔记法）:
C25H33NaO8
化学文摘社编号:
125-04-2
分子量:
484.51
NACRES:
NA.77
PubChem Substance ID:
24895659
UNSPSC Code:
12352209
EC Number:
204-725-5
MDL number:
MFCD00069472
Assay:
≥90% (HPLC)
Form:
powder
Quality level:
200

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产品名称

氢化可的松琥珀酸酯 钠盐, ≥90% (HPLC)

InChI key

HHZQLQREDATOBM-CODXZCKSSA-M

InChI

1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1

SMILES string

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COC(CCC([O-])=O)=O)=O)=C1.[Na+]

biological source

synthetic (organic)

assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NR3C1(2908)

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相关类别

Application

Hydrocortisone 21-hemisuccinate sodium salt has been used:
  • as a component of the maturation medium for hepatic differentiation
  • in the corticosterone (CORT) treatment to study its effect on astrocyte-like neural stem cell proliferation in the area postrema of the adult mouse brain
  • in cortisol incubation experiments to study the effect of cortisol on the expression and function of sodium-chloride cotransporter (NCC) in zebrafish embryos

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361d

Hazard Classifications

Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000529036
0000529037
0000529036
0000529037
0000474142

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Yuri Nambu et al.
Neuroscience letters, 748, 135732-135732 (2021-02-17)
The discovery of neural stem cells (NSCs) in the adult mammalian brain has provided insights into an extra level of brain plasticity. The proliferation and differentiation of NSCs is modulated by various physiological, pathological, and pharmacological stimuli. NSCs were recently
Chia-Hao Lin et al.
Molecular and cellular endocrinology, 422, 93-102 (2015-12-19)
In mammals, sodium/hydrogen exchanger (NHE) and sodium-chloride cotransporter (NCC) are expressed in renal tubules, and exhibit functional redundancy and mutual compensation in Na(+) uptake. In teleosts, the gills of the adult and skin of the embryonic stage function as external
Influence Of Cortisol On The Attachment And Metamorphosis Of Larval Utterbackia Imbecillis On Bluegill Sunfish (Lepomis Macrochirus).
Dubansky, B., et al.
The Biochemical Journal, 220, 97-106 (2011)
Yuri Nambu et al.
Neuroscience letters, 748, 135732-135732 (2021-02-17)
The discovery of neural stem cells (NSCs) in the adult mammalian brain has provided insights into an extra level of brain plasticity. The proliferation and differentiation of NSCs is modulated by various physiological, pathological, and pharmacological stimuli. NSCs were recently
Y Baert et al.
Human reproduction (Oxford, England), 35(5), 1029-1044 (2020-05-12)
Is it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip? Multi-organ-chip co-cultures of human liver and testis equivalents were maintained at a steady-state for at least 1 week and
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