H5270
Hydrocortisone 17-butyrate
别名:
11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate, Cortisol 17-butyrate
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关于此项目
经验公式（希尔记法）:
C25H36O6
化学文摘社编号:
分子量:
432.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-093-4
MDL number:
Form:
solid
Quality level:
InChI
1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
InChI key
BMCQMVFGOVHVNG-TUFAYURCSA-N
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCC)C(=O)CO
form
solid
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... NR3C1(2908)
Application
Hydrocortisone 17-butyrate may be used:
- in the synthesis of hydrocortisone butyrate (HB)-loaded poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles
- as a topical corticosteroid (CS) to study its effects on keratinocyte proliferation in hyperproliferant keratinocytes (HaCaT) model
- in the preparation of solid lipid nanoparticles (SLN)
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Annesofie Faurschou et al.
Archives of dermatology, 144(5), 620-624 (2008-05-21)
To examine the effect of topical corticosteroid treatment on acute sunburn. Randomized, double-blind clinical trial. University dermatology department. Twenty healthy volunteers with Fitzpatrick skin types I (highly sensitive, always burns easily, tans minimally) through III (sun-sensitive skin, sometimes burns, slowly
Joseph F Fowler et al.
Cutis, 75(2), 125-131 (2005-03-19)
This multicenter, randomized, double-blind clinical trial involving 89 subjects (86 with chronic hand dermatitis and 3 with atopic dermatitis) compared the safety, efficacy, and cosmetic acceptability of 4 medium-potency topical corticosteroid products: hydrocortisone butyrate (HB) 0.1% cream (Locoid Lipocream), fluticasone
Mari Paz Castanedo-Tardan et al.
Pediatric dermatology, 26(6), 739-743 (2010-03-05)
Upon ingestion, the artificial sweetener, aspartame is metabolized to formaldehyde in the body and has been reportedly associated with systemic contact dermatitis in patients exquisitely sensitive to formaldehyde. We present a case of a 9-year-old Caucasian boy with a history
Dina Vind-Kezunovic et al.
Contact dermatitis, 64(6), 325-329 (2011-04-05)
Corticosteroids are used to treat dermatoses, including allergic contact dermatitis, but can also cause contact allergy. The frequency of corticosteroid allergy varies between studies and is influenced by treatment traditions and availability. To estimate the prevalence of tixocortol-21-pivalate, budesonide and
P Mercy et al.
Indian journal of dermatology, venereology and leprology, 73(6), 415-416 (2007-11-23)
Acquired Blaschkoid dermatitis characterised by unilateral relapsing inflammatory disease along the lines of Blaschko. A 40-year-old Indian male presented with unilateral erythematous, itchy grouped papules on the left side of the chest, abdomen, back and left arm of 15 days
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