H5270
Hydrocortisone 17-butyrate
别名:
11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate, Cortisol 17-butyrate
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关于此项目
经验公式（希尔记法）:
C25H36O6
化学文摘社编号:
分子量:
432.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-093-4
MDL number:
InChI
1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
InChI key
BMCQMVFGOVHVNG-TUFAYURCSA-N
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCC)C(=O)CO
form
solid
shipped in
ambient
storage temp.
room temp
Quality Level
Gene Information
human ... NR3C1(2908)
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Application
Hydrocortisone 17-butyrate may be used:
- in the synthesis of hydrocortisone butyrate (HB)-loaded poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles
- as a topical corticosteroid (CS) to study its effects on keratinocyte proliferation in hyperproliferant keratinocytes (HaCaT) model
- in the preparation of solid lipid nanoparticles (SLN)
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Caproni et al.
Clinical and experimental dermatology, 31(6), 813-817 (2006-10-17)
Topical tacrolimus represents an effective and well-tolerated treatment for atopic dermatitis (AD). Its known effects include reduced production of proinflammatory cytokines and reduced chemokine gradient. We performed lesional skin biopsies on adult patients affected by moderate-to-severe AD. Then, patients were
Lawrence Eichenfield et al.
Pediatric dermatology, 24(1), 81-84 (2007-02-16)
Corticosteroids are currently the first line of treatment for patients with atopic dermatitis. In the pediatric population however, the potential impact of adrenal suppression is always an important safety concern. Twenty boys and girls, 5-12 years of age, with normal
S Reitamo et al.
The British journal of dermatology, 152(6), 1282-1289 (2005-06-14)
Atopic dermatis (AD) is a chronic disease that often requires long-term treatment. Topical corticosteroids are the usual therapy for patients with AD, but prolonged usage can result in skin atrophy and other side-effects. In a randomized, double-blind, comparative study, to
F Sassi et al.
The British journal of dermatology, 159(5), 1186-1191 (2008-08-23)
Vitiligo is a pigmentary disorder which may have disfiguring consequences. Its treatment remains a challenge. We designed a parallel-group randomized controlled trial to compare the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in
Hidemi Nakagawa
Clinical drug investigation, 26(5), 235-246 (2006-12-14)
Tacrolimus (FK506) ointment is widely used in the treatment of patients with atopic dermatitis. The drug exerts its action by down-regulating antigen-specific T-cell activities and associated proinflammatory cytokine production. A number of clinical studies have evaluated the efficacy and safety
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