H5777
(±)-石杉碱甲
synthetic, ≥98% (TLC)
别名:
(±)-Selagine
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关于此项目
经验公式（希尔记法）:
C15H18N2O
化学文摘社编号:
分子量:
242.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
(±)-石杉碱甲, synthetic, ≥98% (TLC)
InChI
1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
SMILES string
C\C=C1/C2CC3=C(C=CC(=O)N3)C1(N)CC(C)=C2
InChI key
ZRJBHWIHUMBLCN-QDEBKDIKSA-N
biological source
synthetic
assay
≥98% (TLC)
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Gene Information
human ... BCHE(590)
rat ... Ache(83817)
Application
(±)-Huperzine A has been used in anti-acetylcholinesterase bioautographic assay.
Biochem/physiol Actions
Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.
Features and Benefits
Acetylcholinesterase inhibitor.
General description
Huperzine A is an alkaloid derived from Chinese club moss Huperzia serrata.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Coumarins from Peucedanum ostruthium. as Inhibitors of Acetylcholinesterase
Urbain A, et al.
Pharmaceutical biology, 43(8), 647-650 (2005)
Yun Zhou et al.
Planta medica, 75(6), 568-574 (2009-02-14)
Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
X C Tang et al.
Journal of neuroscience research, 24(2), 276-285 (1989-10-01)
The present study represents the first comprehensive investigation of the effect of huperzine A (HUP-A), a new cholinesterase inhibitor (ChEI) isolated from a Lycopodium species, upon acetylcholinesterase (AChE) activity, acetylcholine (ACh) levels and release, and cholinergic receptors in rat brain
Women's Health in Complementary and Integrative Medicine, 138-138 (2004)
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