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H5877

cis-4-Hydroxy-D-proline

Name: <I>cis</I>-4-Hydroxy-<SC>D</SC>-proline
Brand: SIGMA

≥98% (TLC), suitable for ligand binding assays

别名:

(2R,4R)-(+)-4-Hydroxy-2-pyrrolidinecarboxylic acid, D-allo-Hydroxyproline

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关于此项目

经验公式（希尔记法）:

C₅H₉NO₃

化学文摘社编号:

2584-71-6

分子量:

131.13

NACRES:

NA.26

PubChem Substance ID:

24895713

UNSPSC Code:

12352209

EC Number:

219-963-5

MDL number:

MFCD00005252

Beilstein/REAXYS Number:

81439

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属性

产品名称

cis-4-Hydroxy-D-proline,

assay

≥98% (TLC)

Quality Level

100

form

powder

technique(s)

ligand binding assay: suitable

color

white

mp

243 °C (dec.) (lit.)

application(s)

peptide synthesis

SMILES string

O[C@H]1CN[C@H](C1)C(O)=O

InChI

1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m1/s1

InChI key

PMMYEEVYMWASQN-QWWZWVQMSA-N

说明

Biochem/physiol Actions

Cis-4-Hydroxy-D-proline may be used as a starting material for the 13-step synthesis of new conformationally restricted PNA adenine monomer and the synthesis of N-Benzyl pyrrolidinyl sordaricin derivatives. Cis-4-Hydroxy-D-proline is a substrate that may be used to study the specificity and kinetics of D-alanine dehydrogenase. Cis-4-Hydroxy-D-proline may be used to analyze the substrate specificity of amino acid transporter PAT1.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Synthesis and evaluation of novel pyrrolidinyl sordaricin derivatives as antifungal agents.

Masami Arai et al.

Bioorganic & medicinal chemistry letters, 12(19), 2733-2736 (2002-09-10)

N-Benzyl pyrrolidinyl sordaricin derivatives have been synthesized from cis-4-hydroxy-D-proline in a stereocontrolled manner. These compounds maintained moderate antifungal activity against several pathogenic fungal strains. Their MIC values against Candida albicans were in the range of 0.25-2 microg/mL.

Pyrrolidine PNA: a novel conformationally restricted PNA analogue.

A Püschl et al.

Organic letters, 2(26), 4161-4163 (2001-01-11)

[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA

Oxidation of 3,4-dehydro-D-proline and other D-amino acid analogues by D-alanine dehydrogenase from Escherichia coli.

Charles E Deutch

FEMS microbiology letters, 238(2), 383-389 (2004-09-11)

3,4-Dehydro-DL-proline is a toxic analogue of L-proline which has been useful in studying the uptake and metabolism of this key amino acid. When membrane fractions from Escherichia coli strain UMM5 (putA1::Tn5 proC24) lacking both L-proline dehydrogenase and L-Delta(1)-pyrroline-5-carboxylate reductase were

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全球贸易项目编号

货号	GTIN
H5877-10G	04061832416519
H5877-1G	04061826059753
H5877-250MG	04061833799888