H5915
2,3-双(4-羟苯基)丙腈
≥98% (HPLC), estrogen receptor β agonist, powder
别名:
DPN, SC-4473, 二芳基丙腈
产品名称
2,3-双(4-羟苯基)丙腈, ≥98% (HPLC)
无菌性
non-sterile
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
运输
ambient
储存温度
−20°C
SMILES字符串
Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
InChI
1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
InChI key
GHZHWDWADLAOIQ-UHFFFAOYSA-N
相关类别
生化/生理作用
2,3-双（4-羟基苯基）-丙腈是一种ERβ-选择性激动剂； IC50 = 15nM。
2,3-双（4-羟基苯基）-丙腈是一种ERβ-选择性激动剂； IC50 = 15nM。DPN可保护WT和ARKO小鼠，并在年轻成人衍生的小胶质细胞中进行LPS治疗后显著降低IL-1β。PPT（货号H6036，ERa激动剂）可增强细胞增殖，而DPN则对其进行抑制。PPT可提高Bcl-2表达，而DPN则降低它。DPN还可提升Bax的表达。DPN可诱导卵黄蛋白原合成的剂量依赖性增加。在海马神经元中，PPT和DPN可动态但差异地有效调节细胞内钙信号传导。相比于PPT，DPN可更有效的增强这些神经元中谷氨酸诱导的细胞内Ca2+生理浓度的升高。DPN可预防睾酮治疗的LuRKO小鼠中前列腺增生和炎症的发展。
警示用语：
Warning
危险声明
危险分类
Aquatic Acute 1 - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Chew Leng Lim et al.
eLife, 9 (2020-07-25)
There is strong evidence that the pro-inflammatory microenvironment during post-partum mammary involution promotes parity-associated breast cancer. Estrogen exposure during mammary involution drives tumor growth through neutrophils' activity. However, how estrogen and neutrophils influence mammary involution are unknown. Combined analysis of
Thomas J Lechuga et al.
Biology of reproduction, 100(2), 514-522 (2018-10-03)
Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CTH). Estrogens are potent vasodilators that stimulate H2S biosynthesis in uterine arteries (UA) in vivo; however, the underlying
Konstantin Yakimchuk et al.
Endocrine connections, 7(12), 1472-1479 (2018-11-30)
Well-defined physiological functions of estrogens are mediated via nuclear estrogen receptors α (ESR1) and β (ESR2). With regard to hematological malignancies, expression of ESR2 has been found in both B and T cell lymphomas. In addition to endogenous estrogens or
L Hases et al.
Scientific reports, 10(1), 16160-16160 (2020-10-02)
There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor beta (ERβ)
Peiye Song et al.
Journal of experimental & clinical cancer research : CR, 38(1), 354-354 (2019-08-16)
Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not clear. Claudin-6 (CLDN6), a tight junction protein, acts as a tumor suppressor gene
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