H6036
1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑
powder, ≥98% (HPLC)
别名:
PPT
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关于此项目
经验公式（希尔记法）:
C24H22N2O3
化学文摘社编号:
分子量:
386.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑, powder, ≥98% (HPLC)
InChI key
IOTXSIGGFRQYKW-UHFFFAOYSA-N
SMILES string
CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4
InChI
1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: soluble 20 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... ESR1(2099)
Application
已使用 1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑培养分化的脂肪细胞。也用于药物治疗 和放射免疫测定 (RIA)。
Biochem/physiol Actions
PPT 是一种特异性雌激素受体 α(ERα)激动剂。
雌激素受体 α(ERα）参与免疫和炎症反应。ESR1 的异常导致 Mayer-Rokitansky-Kuster-Hauser 综合征，该综合征与先天性子宫和阴道上 2/3 缺失相关。
General description
雌激素受体 α(ERα）是核受体超家族成员。它也被称为 ESR1（雌激素受体）。它位于人类染色体 6q25.1。
1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑也称为 PPT。ERα在主神经元和抑制性神经元的核内和核外部位发现。
1,3,5-三（4-羟基苯基）-4-丙基-1H-吡唑也称为 PPT。ERα在主神经元和抑制性神经元的核内和核外部位发现。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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