H6041
干扰素 α 2A 人
HumanKine®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyopholized powder, suitable for cell culture
别名:
α 2A 干扰素, IFN-α 2A, 人干扰素α 2A
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关于此项目
UNSPSC Code:
12352202
NACRES:
NA.77
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
monomer 16 kDa (glycosylated)
Impurities:
≤1EU/mg
产品名称
干扰素 α 2A 人, IFN-α 2A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤0.4 ng/mL EC50
quality
endotoxin tested
mol wt
monomer 16 kDa (glycosylated)
packaging
glass bottle of 10 μg (in glass bottle)
manufacturer/tradename
HumanZyme
technique(s)
cell culture | mammalian: suitable
impurities
≤1EU/mg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IFNA2(3440)
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General description
IFNA2（干扰素α2）基因定位于人类染色体9p21.3。它被认为是原型I型IFN亚型。编码的蛋白含有165个氨基酸。Ifna2蛋白结构具有五个α螺旋，通过两个二硫键连接。
Application
人干扰素α2A已被用于检查其对基孔肯雅病毒的抗病毒作用。并作为对照检查朝鲜红参的抗病毒细胞因子诱导。
Biochem/physiol Actions
IFNA2是1型干扰素，可作为第一道防线，并提供针对病原体入侵的保护。
干扰素α2A（IFN-α2A）属于I型干扰素蛋白家族，由许多类型的细胞响应病毒感染而产生。其具有抗恶性细胞增生和抗肿瘤活性，并诱导细胞凋亡和炎症反应。IFN-α2A通过增加抗原肽的呈递来增强MHC蛋白的表达，并激活细胞毒性T细胞。
Physical form
从0.2 μm过滤的 1x PBS溶液中冻干。
Preparation Note
人源Kine IFN-α 2A在人HEK 293细胞中表达，是一种糖基化单体，表观分子量为16 kDa。在人HEK293细胞中生成可提供真正的糖基化。糖基化有助于细胞生长培养基和其他应用中的稳定性。
Analysis Note
通过人TF-1细胞系（人红白血病指示细胞系）≤0.4的剂量依赖性细胞毒性测定活性。
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
IFNA2: The prototypic human alpha interferon
Paul F, et al.
Gene, 567(2), 132-137 (2015)
Loss of tumor suppressive microRNA-31 enhances TRADD/NF-kappaB signaling in glioblastoma
Rajbhandari R, et al.
Testing, 6(19), 17805-17805 (2015)
Evaluation of broad-spectrum antiviral compounds against chikungunya infection using a phenotypic screening strategy
Bonotto RM, et al.
F1000Research, 7 (2018)
A R Mire-Sluis et al.
Journal of immunological methods, 195(1-2), 55-61 (1996-09-09)
Interferons-alpha and -beta (IFN-alpha and -beta) are cytokines that are widely known to induce potent anti-viral activity. However, it has become increasingly apparent that IFN-alpha and -beta exert a variety of other biological effects, including anti-tumour and immunomodulatory activities and
Cristina Cheroni et al.
Scientific reports, 11(1), 18043-18043 (2021-09-12)
Interferons (IFNs) are key cytokines involved in alerting the immune system to viral infection. After IFN stimulation, cellular transcriptional profile critically changes, leading to the expression of several IFN stimulated genes (ISGs) that exert a wide variety of antiviral activities.
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