H6291
Interleukin-1β human
IL-1β, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture, endotoxin tested
别名:
IL-1β, 淋巴细胞激活因子
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关于此项目
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 18-25 kDa (glycosylated)
Impurities:
<1 EU/μg
产品名称
白介素1β 人, IL-1β, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture, endotoxin tested
biological source
human
Quality Level
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤0.05 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 18-25 kDa (glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL1B(3553)
Biochem/physiol Actions
白介素-1 (IL-1)，最初称为淋巴细胞激活因子(LAF)，可激活T细胞淋巴细胞，进而增殖并分泌白介素-2 (IL-2)。IL-1主要从受刺激的巨噬细胞和单核细胞释放，但也已显示可从几种其他类型细胞中释放，并且被认为在炎症和免疫应答中起关键作用。IL-1的其他同义词包括：内源性热原(EP)、有丝分裂原蛋白(MP)、辅助峰-1 (lp -1)、T细胞替代因子III（TRF III或TRFM）、B细胞激活因子(BAF)和B细胞分化因子(BDF)。两种关系紧密的试剂白细胞介素-1 α(IL-1α)和白细胞介素-1β (IL-1β)在氨基酸序列上有62%的同源性，引起几乎相同的生物反应。IL-1α和IL-1β的糖基化量都在17 kDa左右，具有一定的异质性。
白介素-1可激活T细胞淋巴细胞，进而增殖并分泌白介素-2 (IL-2)。IL-1主要从受刺激的巨噬细胞和单核细胞释放，但也已显示可从几种其他类型细胞中释放，并且被认为在炎症和免疫应答中起关键作用。
Physical form
从0.2 μm过滤的 1x PBS溶液中冻干。
Preparation Note
人源Kine重组人IL-1β在人HEK 293细胞中表达，是一种糖基化单体，分子量为18-25 kDa。在人HEK293细胞中生成可提供真正的糖基化。糖基化有助于细胞生长培养基和其他应用中的稳定性。
Analysis Note
通过小鼠D10S细胞增殖的剂量依赖性刺激测定活性。
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H6291-5UG | 04061833800652 |
| H6291-10UG | 04061833800645 |