H6666
角质细胞生长因子 人
HumanKine®, >95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
别名:
FGF-7, KGF
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关于此项目
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
>95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 17-30 kDa (glycosylated)
Impurities:
<1 EU/μg
产品名称
角质细胞生长因子 人, KGF, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biological source
human
Quality Level
recombinant
expressed in HEK 293 cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
4-20 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 17-30 kDa (glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FGF7(2252)
General description
Keratinocyte Growth Factor (KGF) belongs to the fibroblast growth factor 7 (FGF-7) family. It is produced by the mesenchymal cells, γδ T cells, and fibroblasts in several organs. The KGF gene is located on the human chromosome at 15q21.2.
Application
Keratinocyte Growth Factor (KGF) human has been used as a component of the keratinocyte differentiation medium.
Biochem/physiol Actions
Keratinocyte Growth Factor (KGF) exerts paracrine effects on mesenchymal cells. It exhibits cryoprotective effects on epithelial cells of the lungs, gastrointestinal tract, and the lungs. KGF participates in the activation of IIIb isoform of the fibroblast growth factor (FGF)-receptor 2 (FGFR2-IIIb) present on keratinocytes. This activation further favors proliferation, migration, and survival of keratinocytes.
Physical form
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Preparation Note
HumanKine Keratinocyte Growth Factor (KGF) is expressed as glycosylated 17 and 30 kDa monomers in human HEK 293 cells. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Analysis Note
The activity was determined by the dose-dependent stimulation of the proliferation of 4MBr-5 cells (monkey epithelial cell line).
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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相关内容
Instructions
Qandeel Fatima et al.
Open life sciences, 13, 544-552 (2018-12-31)
Autologous skin grafts are used to treat severe burn wounds, however, the availability of adequate donor sites makes this option less practical. Recently, stem cells have been used successfully in tissue engineering and in regenerative medicine. The current study aims
Michael J LaFemina et al.
American journal of physiology. Lung cellular and molecular physiology, 299(6), L724-L734 (2010-09-14)
Keratinocyte growth factor (KGF) has efficacy in several experimental models of lung injury; however, the mechanisms underlying KGF's protective effect remain incompletely understood. This study was undertaken to determine whether KGF augments barrier function in primary rat alveolar epithelial cells
Umbilical cord tissue derived mesenchymal stem cells can differentiate into skin cells
Fatima Q, et al.
The Open Immunology Journal, 13(1), 544-552 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H6666-10UG | 04061833801741 |