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H6875

Hippuryl-L-phenylalanine

Name: Hippuryl-<SC>L</SC>-phenylalanine
Brand: SIGMA

别名:

Hippuryl-Phe, N-Benzoyl-Gly-Phe

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₈N₂O₄

化学文摘社编号:

744-59-2

分子量:

326.35

UNSPSC Code:

12352204

NACRES:

NA.32

PubChem Substance ID:

24895770

EC Number:

212-016-7

Beilstein/REAXYS Number:

2167818

MDL number:

MFCD00037265

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assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

acetic acid: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

OC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)c2ccccc2

InChI

1S/C18H18N2O4/c21-16(12-19-17(22)14-9-5-2-6-10-14)20-15(18(23)24)11-13-7-3-1-4-8-13/h1-10,15H,11-12H2,(H,19,22)(H,20,21)(H,23,24)/t15-/m0/s1

InChI key

CCLJGZGVIQBNDH-HNNXBMFYSA-N

General description

Substrate for carboxypeptidase A

Application

Hippuryl-L-phenylalanine has been used as a substrate for screening carboxypeptidase activity in Trogoderma granarium, Bactrocera oleae Gmelin and Apodiphus amygdali.

Biochem/physiol Actions

Hippuryl-L-phenylalanine is a substrate for carboxypeptidase A enzyme.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A novel [125I]iodinated carboxypeptidase A substrate detects a metallopeptidase activity distinct from carboxypeptidase A in brain.

E Normant et al.

Neuropeptides, 30(1), 13-17 (1996-02-01)

We have designed two radioactive substrates, hippuryl-L-[3H]phenylalanine and 3-(p-hydroxy, m-[125I]phenyl)propionic acid ([125I]Bolton reagent) derivative of L-arginyl-L-phenylalanine, i.e. [125I]BRF, for a highly sensitive assay of carboxypeptidase A (CPA) activity. After cleavage of the C-terminal phenylalanine residue by CPA, the radioactive product

Determination of kininase I and kininase II activities in human urine by high-performance liquid chromatography.

G Porcelli et al.

Journal of chromatography, 414(2), 423-428 (1987-03-06)

The role of Tyr248 probed by mutant bovine carboxypeptidase A: insight into the catalytic mechanism of carboxypeptidase A.

J H Cho et al.

Biochemistry, 40(34), 10197-10203 (2001-08-22)

We have investigated the function of Tyr248 using bovine wild-type CPA and its Y248F and Y248A mutants to find that the K(M) values were increased by 4.5-11-fold and the k(cat) values were reduced by 4.5-10.7-fold by the replacement of Tyr248

Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas

Sud M and Dua RD

Journal of Biosciences, 9(1-2), 83-90 (1985)

Mechanisms for activation and inhibition of carboxypeptidase A catalyzed hydrolyses of peptides and esters.

J F Sebastian et al.

Canadian journal of biochemistry, 56(5), 329-333 (1978-05-01)

3,3-Diphenylpropanoate (DPP) activates the carboxypeptidase A catalyzed hydrolysis of benzoylglycyl-L-phenylalanine (BzGly-L-Phe) (Ka = 2.1 x 10 (-3) M) and inhibits ester hydrolysis uncompetitively (K1 =2.1 X 10 (-3) M). A common modifier binding site located adjacent to the peptide and

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实验方案

Enzymatic Assay: Carboxypeptidase

Carboxypeptidase A activity measured via continuous spectrophotometric rate determination assay with hippuryl-L-phenylalanine substrate.

羧肽酶A酶活检测

在测定羧肽酶A活性时，使用马尿酸-L-苯丙氨酸在254nm处进行连续分光光度法测定。羧肽酶A水解C末端残基上的肽键。

全球贸易项目编号

货号	GTIN
H6875-1G	04061833802182
H6875-500MG	04061833802212

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