H6916
巨噬细胞集落刺激因子 人
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
别名:
MCSF
产品名称
巨噬细胞集落刺激因子 人, M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
≤4 ng/mL EC50
quality
endotoxin tested
mol wt
dimer 35-40 kDa (glycosylated)
packaging
pkg of 10 μg
manufacturer/tradename
HumanZyme
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... CSF1(1435)
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Analysis Note
通过鼠类TF-60 细胞（小鼠红白血病指示细胞系）增值的剂量依赖性刺激测定比活性。
Biochem/physiol Actions
巨噬细胞CSF (M-CSF)作为一种生长因子，刺激单核/巨噬细胞系细胞的增殖和分化。它还可增强抗体依赖、单核细胞和巨噬细胞介导的细胞毒性。此外，人M-CSF可抑制破骨细胞的骨吸收。它在动脉粥样硬化中也可能发挥关键作用。在骨骼Paget病(PDB)中观察到该基因的过表达。
General description
M-CSF由定位至人类染色体1p13.3上的基因所编码。它是一种糖基化多肽，以同二聚体的形式存在。M-CSF由巨噬细胞、成纤维细胞、淋巴细胞和内皮细胞产生。
Physical form
从0.2 μm过滤的 1x PBS溶液中冻干。
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
Albagha O M E, et al.
Nature Genetics, 429(6), 520-520 (2010)
"Effects of macrophage colony-stimulating factor (M-CSF) on protease production from monocyte, macrophage and foam cell in vitro: a possible mechanism for anti-atherosclerotic effect of M-CSF.
Tojo N, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1452.3, 275-284 (1999)
The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors.
Metcalf D.
Blood, 67(2), 257-267 (1986)
Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone.
Hattersley G, et al.
Journal of Cellular Physiology, 137(1), 199-203 (1988)
Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity.
Mufson R A, et al.
Cellular Immunology, 119(1), 182-192 (1989)
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