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Merck
CN

H7017

血蓝蛋白 来源于大锁孔帽贝 (透孔螺)

别名:

KLH, 钥孔戚血蓝蛋白

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
Form:
powder
Biological source:
Megathura crenulata
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biological source

Megathura crenulata

Quality Level

form

powder

packaging

vial of KLH (KLH is present by weight at approximately 1 part KLH to 5 parts total solid.)

technique(s)

ELISA: suitable

solubility

H2O: soluble

storage temp.

2-8°C

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General description

腹足类血青素是一种大型糖蛋白(4到8 MDa),由10个亚基的复杂排列设计而成,这些亚基自组装成直径35纳米的空心圆柱体。
血青蛋白是一种高分子量的含铜糖蛋白。它可逆的与氧气结合,形成软体动物的细胞外呼吸蛋白。钉形贝血蓝蛋白(KLH)是由 巨齿蛇血淋巴过滤得到,也被称为巨星钥孔虫。它原产于南加州海岸和墨西哥。

Application

钉形贝血蓝蛋白(KLH)是一种在实验动物和人类中强大的和众所周知的免疫刺激剂。它已被用作半抗原载体蛋白,以增强抗原特异性T细胞启动,并已知可刺激CD4+ T细胞反应。血红素刺激Th1反应而没有已知的副作用,这使它们成为长期连续治疗癌症的理想药物。

Physical form

稳定缓冲盐冻干

Preparation Note

采用去离子水复配KLH浓度为10 mg/mL,在含0.46 M NaCl、2% PVP和41 mM蔗糖的31 mM磷酸钠缓冲液,pH 7.4中,得到乳白色溶液。
复溶的蛋白溶液液可在−20°C保存长达2个月。

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

动物来源生物产品

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Traumatic aneurysm of the internal carotid artery with fracture dislocation at C 5: case report.
H Wada et al.
Neurosurgical review, 12 Suppl 1, 600-601 (1989-01-01)
L R Ferguson et al.
Mutation research, 158(1-2), 89-95 (1985-10-01)
The tannins, delphinidin and procyanidin were isolated from flowers of white clover (Trifolium repens) and the leaves of Arnot Bristly Locust (Robina fertilis) respectively, and tested for mutagenic properties in a range of systems. There was no evidence for either
Tingting Chen et al.
Cancer biology & medicine, 17(1), 132-141 (2020-04-17)
Objective: Cancer stem cell is one of the important causes of tumorigenesis as well as a drug target in the treatment of malignant tumor. However, at present, there is no immune vaccine targeting these cells. Octamer-binding transcription factor 4 (OCT4)
István Fodor et al.
General and comparative endocrinology, 299, 113621-113621 (2020-09-24)
In the last years, our interpretation of the origin and function of the gonadotropin-releasing hormone (GnRH) neuropeptide superfamily has changed substantially. A main driver for these conceptual changes came from increased investigations into functions and evolutionary lineage of previously identified

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全球贸易项目编号

货号GTIN
H7017-20MG04061833802960
H7017-5X20MG04061833803011
H7017-50MG04061833802977

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