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Merck
CN

H7040

Anti-Herp (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-HERPUD1, Anti-Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, MMS-inducible, Anti-Methyl methanesulfonate (MMF)-inducible fragment protein 1, SUP, Anti-Mif1

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~54 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2-4 μg using lysate of HEK-293T cells expressing human Herp, indirect immunofluorescence: suitable, western blot: 1-2 μg/mL using whole extract of HEK-293T cells expressing human Herp

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... HERPUD1(9709)
mouse ... Herpud1(64209)
rat ... Herpud1(85430)

Biochem/physiol Actions

Anti-Herp (N-terminal) recognizes human Herp.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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flash_point_f

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flash_point_c

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ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

wgk

nwg

存储类别

12 - Non Combustible Liquids

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K Kokame et al.
The Journal of biological chemistry, 275(42), 32846-32853 (2000-08-03)
Hyperhomocysteinemia, a risk factor for vascular disease, injures endothelial cells through undefined mechanisms. We previously identified several homocysteine-responsive genes in cultured human vascular endothelial cells, including the endoplasmic reticulum (ER)-resident molecular chaperone GRP78/BiP. Here, we demonstrate that homocysteine induces the
Andrea Schulze et al.
Journal of molecular biology, 354(5), 1021-1027 (2005-11-18)
To eliminate misfolded proteins that accumulate in the endoplasmic reticulum (ER) the cell mainly relies on ubiquitin-proteasome dependent ER-associated protein degradation (ERAD). Proteolysis of ERAD substrates by the proteasome requires their ubiquitylation and retro-translocation from the ER to the cytoplasm.